Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting

Werner Koch¹^,*, Julinda Mehilli^*, Arne Pfeufer^,, Albert Schömig^* and Adnan Kastrati^*

^* Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
Institut für Humangenetik, Klinikum rechts der Isar, Technische Universität München, München, Germany
GSF-Institut für Humangenetik, Neuherberg, Germany

^¹ To whom correspondence should be addressed. e-mail: wkoch{at}dhm.mhn.de

Experimental data support a protective function of apolipoproteinE (apoE) against restenosis, the main factor limiting the long-termbenefit of percutaneous coronary interventions. We investigatedthe possibility that the single nucleotide polymorphisms (SNPs)–219G/T, 113G/C, 334T/C, and 472C/T of the gene encodingapoE (APOE) are associated with the incidence of death and myocardialinfarction or restenosis after stenting in coronary arteries.In addition, we asked whether the apoE isotype-related ${varepsilon}$ 2/ ${varepsilon}$ 3/ ${varepsilon}$ 4polymorphism, defined by specific allele combinations (haplotypes)of the 334T/C and 472C/T polymorphism, and other APOE haplotypes,derived from all four SNPs investigated, are associated withadverse clinical and angiographic outcomes after stenting. Ourstudy included 1,850 consecutive patients with symptomatic coronaryartery disease (CAD) who underwent stent implantation. Follow-upangiography was performed in 1,556 patients (84.1%) at 6 monthsafter the intervention. We found that none of the APOE SNPsis associated with death and myocardial infarction or restenosisafter stenting. In addition, we observed no relationship betweenAPOE haplotypes and adverse outcomes.

In conclusion, the APOE –219G/T, 113G/C, 334T/C, and 472C/Tpolymorphisms, either alone or in combination, do not representgenetic markers of the risk of thrombotic and restenotic complicationsin patients with CAD treated with coronary stenting.

Abbreviations: apoE, apolipoprotein E; APOE, gene encoding apolipoprotein E, CAD, coronary artery disease; CI, confidence interval; SNP, single nucleotide polymorphism

Supplementary key words coronary artery disease • APOE ${varepsilon}$ alleles • APOE haplotypes • TaqMan genotyping

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