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Journal of Lipid Research, Vol. 45, 2331-2338, December 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men

Sophie Desroches^*,, Marie-Eve Paradis^*,, Mélanie Pérusse^*, W. Roodly Archer^*,, Jean Bergeron, Patrick Couture^*,, Nathalie Bergeron^*, and Benoît Lamarche^1,*,,

^* Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada
Department of Food Sciences and Nutrition, Laval University, Québec, Canada
Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada

¹ To whom correspondence should be addressed. e-mail: benoit.lamarche{at}inaf.ulaval.ca

The impact of a low-fat diet and a high-MUFA diet on apolipoprotein A-I (apoA-I), apoA-II, and VLDL-apoB-100 metabolism in conditions of unrestricted (ad libitum) energy intake was compared in 65 men randomly assigned to one of two predefined experimental diets. A subsample of 18 men participated in the kinetic study. Before and after the 6–7 week dietary intervention, kinetic subjects received a primed-constant infusion of [5,5,5-²H₃]L-leucine for 12 h under feeding conditions. ApoA-I production rate (PR; –31.5%; P < 0.001) and fractional catabolic rate (FCR; –24.3%; P < 0.05) were significantly decreased after the low-fat diet. These changes in apoA-I PR and FCR with the low-fat diet were also significantly different from those observed with the high-MUFA diet (P < 0.01 and P < 0.05, respectively). ApoA-II FCR was significantly increased in the high-MUFA group only. No significant within- or between-diet difference was found in VLDL-apoB-100 PR or FCR.

These results emphasize the differential impact of the low-fat diet and high-MUFA diet on HDL metabolism.

Abbreviations: apoA-I, apolipoprotein A-I; CHD, coronary heart disease; CHO, carbohydrate; FCR, fractional catabolic rate; HDL-C, HDL-cholesterol; IEF, isoelectric focusing; LDL-C, LDL-cholesterol; PR, production rate; TG, triglyceride

Supplementary key words high density lipoprotein • very low density lipoprotein • apolipoprotein kinetics

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