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Journal of Lipid Research, Vol. 45, 410-418, March 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Review

Discovery of new G protein-coupled receptors for lipid mediators

Dong-Soon Im¹

Laboratory of Pharmacology, College of Pharmacy, Pusan National University, San 30, Chang-Jun-dong, Keum-Jung-gu, Busan 609-735, Republic of Korea

¹ To whom correspondence should be addressed. e-mail: imds{at}pusan.ac.kr

Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas is the research on orphan G protein-coupled receptors (GPCRs). Many intercellular mediators, including peptides, lipids, and other small molecules, have found their GPCRs in the plasma membrane, e.g., relaxin and tyramine. In the past 14 months, more than one dozen papers have been published reporting the finding of intercellular lipid mediators acting on rhodopsin family GPCRs.

This review focuses primarily on intercellular lipid mediators and their recently discovered GPCRs.

Abbreviations: doPA, dioleoylphosphatidic acid; GI, gastrointestinal; GFP, green fluorescent protein; GPCR, G protein-coupled receptor; 5-HETE, 5-hydroxy-eicosatetraenoic acid; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; 5-oxo-ETE, 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5(S)-HPETE, 5(S)-hydroxyperoxy-eicosatetraenoic acid; S1P, sphingosine 1-phosphate; SPC, sphingosylphosphorylcholine

Supplementary key words orphan receptor • sphingosine • fatty acid • bile acid

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