HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: M300363-JLR200v1 45/4/674    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tai, E. S. Articles by Ordovas, J. M. Search for Related Content PubMed PubMed Citation Articles by Tai, E. S. Articles by Ordovas, J. M. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 45, 674-685, April 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Differential effects of the C1431T and Pro12Ala PPAR gene variants on plasma lipids and diabetes risk in an Asian population

E. Shyong Tai^*, Dolores Corella^,, Mabel Deurenberg-Yap^**, Xian Adiconis, Suok Kai Chew, Chee Eng Tan^* and Jose M. Ordovas^1,

^* Department of Endocrinology, Singapore General Hospital, Singapore 169608
Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
Nutrition and Genomics Laboratory, Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
^** Research and Information Management Division, Health Promotion Board, Singapore 168937
Epidemiology and Disease Control Division, Ministry of Health, Singapore 169854

¹ To whom correspondence should be addressed. e-mail: jose.ordovas{at}tufts.edu

We investigated the association of C1431T and Pro12Ala polymorphisms at the peroxisome proliferator-activated receptor (PPAR) locus with plasma lipids and insulin resistance-related variables, according to diabetes status, in a large and representative Asian population from Singapore consisting of 2,730 Chinese, 740 Malays, and 568 Indians. Moreover, we estimated the diabetes risk and examined gene-nutrient interactions between these variants and the ratio of polyunsaturated fatty acid to saturated fat (SFA) in determining body mass index (BMI) and fasting insulin. We found differential effects of these gene variants. The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes. Carriers of the 12Ala allele had higher HDL-cholesterol than did Pro12Pro homozygotes (P < 0.05), and the effect of the 12Ala allele on fasting glucose was modified by diabetes status (P < 0.001). After controlling for confounders, carriers of the T allele had decreased risk of diabetes compared with CC homozygotes [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.58–0.93; P = 0.011]; this effect was stronger in Indians (OR 0.38, 95% CI 0.15–0.92; P = 0.032).

For both polymorphisms, normal subjects carrying the less prevalent allele had higher BMI (P < 0.05). The PUFA/SFA did not modify the effect of these polymorphisms on BMI or insulin.

Supplementary key words peroxisome proliferator-activated receptor • polymorphism • insulin • body mass index • fat • diet

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. A Ruiz-Narvaez, P. Kraft, and H. Campos Ala12 variant of the peroxisome proliferator-activated receptor-{gamma} gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1238 - 1242. [Abstract] [Full Text] [PDF]

				J. C. Florez, K. A. Jablonski, M. W. Sun, N. Bayley, S. E. Kahn, H. Shamoon, R. F. Hamman, W. C. Knowler, D. M. Nathan, D. Altshuler, et al. Effects of the Type 2 Diabetes-Associated PPARG P12A Polymorphism on Progression to Diabetes and Response to Troglitazone J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1502 - 1509. [Abstract] [Full Text] [PDF]

				A. Tonjes, M. Scholz, M. Loeffler, and M. Stumvoll Association of Pro12Ala Polymorphism in Peroxisome Proliferator-Activated Receptor {gamma} With Pre-Diabetic Phenotypes: Meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care, November 1, 2006; 29(11): 2489 - 2497. [Abstract] [Full Text] [PDF]

				W.-P. Koh, J.-M. Yuan, D. Van Den Berg, S. A. Ingles, and M. C. Yu Peroxisome proliferator-activated receptor (PPAR) {gamma} gene polymorphisms and colorectal cancer risk among Chinese in Singapore Carcinogenesis, September 1, 2006; 27(9): 1797 - 1802. [Abstract] [Full Text] [PDF]

				V. Radha, K. S. Vimaleswaran, H. N. S. Babu, N. Abate, M. Chandalia, P. Satija, S. M. Grundy, S. Ghosh, P. P. Majumder, R. Deepa, et al. Role of Genetic Polymorphism Peroxisome Proliferator-Activated Receptor-{gamma}2 Pro12Ala on Ethnic Susceptibility to Diabetes in South-Asian and Caucasian Subjects: Evidence for heterogeneity Diabetes Care, May 1, 2006; 29(5): 1046 - 1051. [Abstract] [Full Text] [PDF]

				E Ruiz-Narvaez Is the Ala12 variant of the PPARG gene an "unthrifty allele"? J. Med. Genet., July 1, 2005; 42(7): 547 - 550. [Abstract] [Full Text] [PDF]