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Journal of Lipid Research, Vol. 45, 1132-1139, June 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

The lipoprotein lipase S447X polymorphism and plasma lipids

J. Lee^*, C. S. Tan^*, K. S. Chia^*, C. E. Tan^*,, S. K. Chew, J. M. Ordovas^** and E. S. Tai^1,*,

^* National University of Singapore-Genome Institute of Singapore Center for Molecular Epidemiology, Community, Occupational and Family Medicine, Singapore
National University of Singapore, Singapore General Hospital, Singapore
Ministry of Health, Singapore
^** Jean Mayer Human Nutrition Research Centre on Aging, Tufts University, Boston, MA

¹ To whom correspondence should be addressed. e-mail: eshyong{at}pacific.net.sg

We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and 2) to explore any interactions with apolipoprotein E (APOE) genotype, exercise, obesity, cigarette smoking, and alcohol intake. Information on obesity, lifestyle factors (including smoking, alcohol consumption, and exercise frequency), glucose tolerance, and fasting lipids was obtained. Male and female carriers of the X447 allele had lower serum triglyceride concentrations and higher HDL cholesterol (HDL-C) concentrations. The association between the X447 allele and serum HDL-C concentration was modulated by APOE genotype in males and cigarette smoking and alcohol intake in females. The effect of the X447 allele was greatest in men who carried the E4 allele and women who smoked or consumed alcohol.

The X447 allele at the LPL locus is common and associated with a less atherogenic lipid profile in Asian populations. Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest.

Abbreviations: ANCOVA, analysis of covariance; apoE, apolipoprotein E; BMI, body mass index; CHD, coronary heart disease; CV, coefficient of variation; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TG, triglyceride; TRL, triglyceride-rich lipoprotein

Supplementary key words apolipoprotein E • gene-gene interaction • gene-environment interaction • triglycerides • ethnic groups

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