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Journal of Lipid Research, Vol. 45, 1583-1593, September 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology
Thematic Review |
Department of Medicine, University of California San Diego, La Jolla, CA 92093-0682
2 To whom correspondence should be addressed. e-mail: dsteinberg{at}ucsd.edu
This is the first of a series of reviews of the controversy that swirled around the "lipid hypothesis" of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of decreasing blood cholesterol levels. In fact, "the lower the better" is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement.
The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future.
Supplementary key words atherosclerosis • plasma cholesterol • lipoproteins • coronary heart disease • N. N. Anitschkow • J. W. Gofman • analytical ultracentrifuge • atherogenic index • experimental atherosclerosis • rabbit model of atherosclerosis
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