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Originally published In Press as doi:10.1194/jlr.M400098-JLR200 on June 21, 2004

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Journal of Lipid Research, Vol. 45, 1624-1632, September 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice

Naoki Ishimori*, Renhua Li*, Peter M. Kelmenson*, Ron Korstanje*, Kenneth A. Walsh*, Gary A. Churchill*, Kristina Forsman-Semb{dagger} and Beverly Paigen1,*

* The Jackson Laboratory, Bar Harbor, ME
{dagger} AstraZeneca R&D Mölndal, Mölndal, Sweden

1 To whom correspondence should be addressed. e-mail: bjp{at}jax.org

The plasma lipid concentrations and obesity of C57BL/6J (B6) and 129S1/SvImJ (129) inbred mouse strains fed a high-fat diet containing 15% dairy fat, 1% cholesterol, and 0.5% cholic acid differ markedly. To identify the loci controlling these traits, we conducted a quantitative trait loci (QTL) analysis of 294 (B6 x 129) F2 females fed a high-fat diet for 14 weeks. Non-HDL cholesterol concentrations were affected by five significant loci: Nhdlq1 [chromosome 8, peak centimorgan (cM) 38, logarithm of odds [LOD] 4.4); Nhdlq4 (chromosome 10, cM 70, LOD 4.0); Nhdlq5 (chromosome 6, cM 0) interacting with Nhdlq4; Nhdlq6 (chromosome 7, cM 10) interacting with Nhdlq1; and Nhdlq7 (chromosome 15, cM 0) interacting with Nhdlq4. Triglyceride (TG) concentrations were affected by three significant loci: Tgq1 (chromosome 18, cM 42, LOD 3.2) and Tgq2 (chromosome 9, cM 66) interacting with Tgq3 (chromosome 4, cM 58). Obesity measured by percentage of body fat mass and body mass index was affected by two significant loci: Obq16 (chromosome 8, cM 48, LOD 10.0) interacting with Obq18 (chromosome 9, cM 65).

Knowing the genes for these QTL will enhance our understanding of obesity and lipid metabolism.

Abbreviations: BMI, body mass index; cM, centimorgan; LOD, logarithm of odds; % fat, percentage of body fat mass; PLTP, phospholipid transfer protein; QTL, quantitative trait loci; SSLP, simple sequence length polymorphic; TG, triglyceride

Supplementary key words body fat mass • body mass index • high-fat diet • non-high density lipoprotein cholesterol • quantitative trait loci • triglyceride


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