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Journal of Lipid Research, Vol. 46, 2037-2051, October 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology
Thematic Review |
Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia1
Department of Medicine, University of California San Diego, La Jolla, CA
1 Based in part on the author's book in preparation, The Cholesterol Wars.
Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.R500010-JLR200
2 To whom correspondence should be addressed. e-mail: dsteinberg{at}ucsd.edu
In this third installment of the series, we point out that the absence of an explicit, detailed and plausible hypothesis linking hypercholesterolemia to the events in the artery wall was probably an important reason for continuing skepticism and for failure to treat elevated blood cholesterol levels.
The rapid advances in understanding of lipoprotein metabolism in the 1950s and 1960s and the application of modern cellular biology in the 1970s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis.
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