J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Originally published In Press as doi:10.1194/jlr.M500192-JLR200 on August 1, 2005

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Journal of Lipid Research, Vol. 46, 2265-2277, October 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Relation between insulin resistance and fast-migrating LDL subfraction as characterized by capillary isotachophoresis

Bo Zhang1,*, Takuya Kaneshi{dagger}, Takao Ohta{dagger} and Keijiro Saku*

* Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
{dagger} Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan

Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500192-JLR200

1 To whom correspondence should be addressed. e-mail: bozhang{at}fukuoka-u.ac.jp

in re-

The proportion of the electronegative low density lipoprotein [LDL(–)] subfraction, which is atherogenic, is increased in type 2 diabetes but is not reduced by glycemic control. Therefore, we evaluated the ability of a new technique, capillary isotachophoresis (cITP), to quantify charge-based LDL subfractions and examined the relation between insulin resistance and the cITP fast-migrating (f) LDL levels. Seventy-five 10-year-old boys were included. The two cITP LDL subfractions, fLDL and major LDL subfractions, were proportional to the LDL protein content within the range of 0.1–0.8 mg/ml LDL protein. Levels of cITP fLDL were positively correlated with triglyceride (TG) levels and negatively correlated with LDL size. Insulin resistance as assessed by the homeostasis model assessment (HOMA-IR) was positively correlated (P < 0.01) with cITP fLDL levels (r = 0.41). The relation between HOMA-IR and cITP fLDL levels depended on TG levels but was independent of body mass index and LDL size.

cITP lipoprotein analysis is an accurate and sensitive method for quantifying charge-based LDL subfractions in human plasma, and insulin resistance is related to cITP fLDL independent of LDL size.

Supplementary key words children • plasma lipoprotein subfraction • low density lipoprotein size • electronegative low density lipoprotein


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B. Zhang, Y. Uehara, S. Hida, S.-i. Miura, D. L. Rainwater, M. Segawa, K. Kumagai, K.-A. Rye, and K. Saku
Effects of reconstituted HDL on charge-based LDL subfractions as characterized by capillary isotachophoresis
J. Lipid Res., May 1, 2007; 48(5): 1175 - 1189.
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