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Journal of Lipid Research, Vol. 46, 196-200, February 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Rapid Communication

Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles

Axel Schlitt^1,*, Mohammad R. Hojjati^*, Hans von Gizycki^*, Karl J. Lackner, Stefan Blankenberg, Bernhard Schwaab, Juergen Meyer, Hans J. Rupprecht and Xian-Cheng Jiang^1,*

^* Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY
Department of Medicine II and Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany
Curschmann Clinic, Timmendorfer Strand, Germany

¹ To whom correspondence should be addressed. e-mail: axelschlitt{at}gmx.net (A.S.); xjiang{at}downstate.edu (X-C.J.)

ABSTRACT

It is known that sphingomyelin (SM) content is higher in apolipoprotein B-containing particles (BLps) than in high density lipoproteins and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis. To evaluate the relationship between serum SM and postprandial remnant particle levels, we determined SM, triglyceride (TG), and cholesterol levels in serum and in remnant-like particles (RLPs) before and 3, 5, 7, and 10 h after a high-fat meal in 31 healthy subjects. We found that serum SM, like serum TG, was increased to its maximum 3 h after fat loading and then gradually decreased to basal levels after 10 h. More important, we determined that SM and TG levels in RLPs were parallel. Serum SM was positively correlated with serum TG (P < 0.001), RLP SM (P < 0.001), RLP TG (P < 0.001), and RLP cholesterol (P < 0.001) levels.

It is our conclusion that serum SM is a marker for the clearance of RLPs.

Abbreviations: apoA-I, apolipoprotein A-I; BLp, apolipoprotein B-containing particle; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; RLP, remnant-like particle; SM, sphingomyelin; TG, triglyceride; TRL, triglyceride-rich lipoprotein

Supplementary key words lipid • lipoprotein • atherosclerosis

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