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Originally published In Press as doi:10.1194/jlr.M400252-JLR200 on December 1, 2004

Papers In Press, published online ahead of print February 1, 2005
J. Lipid Res., doi:10.1194/jlr.M400252-JLR200
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Journal of Lipid Research, Vol. 46, 281-286, February 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE Family Study

Mary F. Feitosa1,*, Ingrid B. Borecki*,{dagger}, Tuomo Rankinen§, Treva Rice*, Jean-Pierre Després**, Yvon C. Chagnon{dagger}{dagger}, Jacques Gagnon§§, Arthur S. Leon***, James S. Skinner{dagger}{dagger}{dagger}, Claude Bouchard§, Michael A. Province* and D. C. Rao*,{dagger},****

* Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO
{dagger} Department of Genetics, Washington University School of Medicine, Saint Louis, MO
**** Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO
§ Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA
** The Québec Heart Institute, Québec, Canada
{dagger}{dagger} Department of Genetic and Molecular Psychiatry, Laval University Research Center Robert Giffard, Beauport, Canada
§§ Centre de Recherche sur les Biotechnologies Marines, Marine Biotechnology Research Center, Québec, Canada
*** School of Kinesiology, University of Minnesota, Minneapolis, MN
{dagger}{dagger}{dagger} Department of Kinesiology, Indiana University, Bloomington, IN

1 To whom correspondence should be addressed. e-mail: maryf{at}wubios.wustl.edu

Genome-wide multipoint linkage analyses were performed to identify chromosomal regions harboring genes influencing LDL-cholesterol, total apolipoprotein B (apoB), and LDL-apoB levels using 654 markers. They were assessed in a sedentary state (baseline) and after a 20 week endurance training program. Strong evidence for two quantitative trait loci (QTLs) for baseline levels was found. There is linkage evidence in black families on chromosomes 1q41-q44 [at marker D1S2860, 238 centimorgan (cM), with a maximum log of the odds (LOD) score of 3.7 for LDL-apoB] and in white families on chromosome 8q24 (at marker D8S1774, 142 cM, with LOD scores of 3.6, 3.3, and 2.5 for baseline LDL-cholesterol, LDL-apoB, and apoB, respectively). There were no strong signals for the lipoprotein training responses (as computed as the difference in posttraining minus baseline levels).

In conclusion, QTLs for baseline apoB and LDL-cholesterol levels on chromosomes 1q41-q44 (in blacks) and 8q24 (in whites) were found. As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed.

Supplementary key words lipids • lipoproteins • genetics • exercise • risk factors • coronary heart disease • genome scan • linkage analysis • quantitative trait loci • low density lipoprotein • apolipoprotein B


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