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Originally published In Press as doi:10.1194/jlr.M400438-JLR200 on December 1, 2004

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Journal of Lipid Research, Vol. 46, 350-355, February 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Phosphatidylinositol increases HDL-C levels in humans

Jim W. Burgess*, Tracey A-M. Neville*,{dagger}, Patricia Rouillard*, Zdena Harder{dagger}, Donald S. Beanlands{dagger} and Daniel L. Sparks1,*,{dagger}

* Liponex, Inc., Ottawa, Ontario, Canada, K2G 3R8
{dagger} University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7

1 To whom correspondence should be addressed. e-mail: dsparks{at}ottawaheart.ca

Studies have shown that phosphatidylinositol (PI) can stimulate reverse cholesterol transport by enhancing the flux of cholesterol into HDL and by promoting the transport of high density lipoprotein-cholesterol (HDL-C) to the liver and bile. The goal of this study was to determine the safety and therapeutic value of PI after oral administration to normolipidemic human subjects. We performed a randomized 2 week study in 16 normolipidemic subjects. Subjects received either 2.8 or 5.6 g of PI, with or without food. PI was well tolerated by all subjects. PI significantly affected the levels of HDL-C and triglyceride in the plasma of subjects receiving PI with food. The lower dose showed a 13% increase in HDL-C, whereas the high dose showed an increase of 18% over the 2 week period. Both low- and high-dose groups showed significant increases in plasma apolipoprotein A-I. The high dose of PI also decreased plasma triglycerides by 36% in the fed subjects.

These data suggest that after only 2 weeks, PI may have a comparable therapeutic value to niacin, with negligible side effects.

Abbreviations: CAD, coronary artery disease; CETP, cholesteryl ester transfer protein; HDL-C, high density lipoprotein-cholesterol; LDL-C, low density lipoprotein-cholesterol; PI, phosphatidylinositol

Supplementary key words high density lipoprotein-cholesterol • cholesterol • triglycerides • HDL elevating agents


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