J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Originally published In Press as doi:10.1194/jlr.M400290-JLR200 on December 16, 2004

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Journal of Lipid Research, Vol. 46, 452-457, March 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population

Francisco J. Tinahones1,*, Juan Miguel Gómez-Zumaquero{dagger}, Lourdes Garrido-Sánchez{dagger}, Eduardo García-Fuentes{dagger}, Gemma Rojo-Martínez{dagger}, Isabel Esteva*, Maria Soledad Ruiz de Adana*, Fernando Cardona{dagger} and Federico Soriguer*

* Servicio de Endocrinología y Nutrición, Carlos Haya Regional University Hospital, Málaga, Spain
{dagger} Laboratorio de Investigación, Carlos Haya Regional University Hospital, Málaga, Spain

1 To whom correspondence should be addressed. e-mail: fjtinahones{at}terra.es

Most studies of antibodies to oxidized LDL have been undertaken in patients with different diseases and cardiovascular risk factors. However, very few studies have researched the distribution and determining factors of antibodies to oxidized LDL in the general population. A total of 1,354 persons (817 females and 537 males) aged 5–65 years were included in this study. They were selected randomly from the population census of Málaga, in southern Spain. The females had lower levels of total cholesterol and triglycerides and higher levels of HDL-cholesterol and a very significant increase (P < 0.0001) in levels of anti-oxidized LDL [low density lipoprotein modified by malondialdehyde (MDA-LDL)] antibodies but no difference in levels of immune complexes consisting of LDL and IgG antibodies (anti-LDL immune complex). Younger persons (16–35 years) had higher levels of anti-oxidized LDL (MDA-LDL) antibodies than persons older than 35 years (P = 0.05). Levels of immune complexes were significantly higher (P = 0.05) in persons aged 5–15 years than in persons older than 40 years. A very weak association was found between levels of anti-oxidized LDL (MDA-LDL) antibodies and anti-LDL immune complexes.

The higher prevalence of anti-oxidized LDL (MDA-LDL) antibodies in females and young persons is in agreement with studies that found an inverse association between atherosclerosis and the level of these antibodies.

Abbreviations: MDA, malondialdehyde; MDA-LDL, low density lipoprotein modified by malondialdehyde

Supplementary key words low density lipoprotein • oxidized low density lipoproteins • atherosclerosis


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