| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Lipid Research, Vol. 46, 1081-1092, June 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology
Thematic Review |
* Department of Pathology, University of Washington, Seattle, WA
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.R500004-JLR200
1 To whom correspondence should be addressed. e-mail: ewraines{at}u.washington.edu
The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing receptors for these cytokines. Although cytokines were originally characterized for their potent effects on immune and inflammatory cells, they also promote endothelial cell dysfunction and alter smooth muscle cell (SMC) phenotype and function, which can contribute to or retard vascular pathologies.
This review summarizes in vivo studies that have characterized endothelial- and smooth muscle-specific effects of altering cytokine signaling in vascular disease. Although multiple reports have identified cytokines as pivotal players in endothelial and SMC responses in vascular disease, they also have highlighted the need to delineate the critical genes and specific cellular functions regulated by individual cytokine signaling pathways.
Abbreviations: apoE, apoplipoprotein E; CCL, CC chemokine ligand; CCR, CC chemokine receptor; CD40L, CD40 ligand; GRO, growth-related oncogene; ICAM, intercellular adhesion molecule; IFN, interferon; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; KC, keratinocyte chemokine; MCP, monocyte chemoattractant protein; MHC, major histocompatibility complex; MIF, macrophage migration inhibitory factor; NF-
B, nuclear factor B; SCID, severe combined immunodeficient; SDF, stromal cell-derived factor; SMC, smooth muscle cell; TGF, transforming growth factor; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule
Supplementary key words atherosclerosis • chemokine • injury • adhesion molecule • survival • proliferation • antigen presentation • extracellular matrix • inflammation • signaling
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Li, M. A. Reddy, F. Miao, N. Shanmugam, J.-K. Yee, D. Hawkins, B. Ren, and R. Natarajan Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-{kappa}B-dependent Inflammatory Genes: RELEVANCE TO DIABETES AND INFLAMMATION J. Biol. Chem., September 26, 2008; 283(39): 26771 - 26781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Reddy, L. M. Villeneuve, M. Wang, L. Lanting, and R. Natarajan Role of the Lysine-Specific Demethylase 1 in the Proinflammatory Phenotype of Vascular Smooth Muscle Cells of Diabetic Mice Circ. Res., September 12, 2008; 103(6): 615 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tian, L. J. Sommerville, A. Cuneo, S. E. Kelemen, and M. V. Autieri Expression and Suppressive Effects of Interleukin-19 on Vascular Smooth Muscle Cell Pathophysiology and Development of Intimal Hyperplasia Am. J. Pathol., September 1, 2008; 173(3): 901 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Doran, N. Meller, and C. A. McNamara Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis Arterioscler. Thromb. Vasc. Biol., May 1, 2008; 28(5): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Loppnow, K. Werdan, and M. Buerke Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms Innate Immunity, April 1, 2008; 14(2): 63 - 87. [Abstract] [PDF]
|
|
|
|
 |
|
 R. R. S. Packard and P. Libby Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction Clin. Chem., January 1, 2008; 54(1): 24 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Liu, M. Han, and J.-K. Wen Acetylbritannilactone Inhibits Neointimal Hyperplasia after Balloon Injury of Rat Artery by Suppressing Nuclear Factor-{kappa}B Activation J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 292 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simionescu Implications of Early Structural-Functional Changes in the Endothelium for Vascular Disease Arterioscler. Thromb. Vasc. Biol., February 1, 2007; 27(2): 266 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. L. Robertson and G. K Hansson T Cells in Atherogenesis: For Better or For Worse? Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kohl, S. Preiss, A. von Knethen, and B. Brune Oxidized low-density lipoprotein depletes PKC{alpha} and attenuates reactive oxygen species formation in monocytes/macrophages Cardiovasc Res, August 1, 2006; 71(3): 574 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pauletto and M. Rattazzi Inflammation and hypertension: the search for a link Nephrol. Dial. Transplant., April 1, 2006; 21(4): 850 - 853. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
