J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Originally published In Press as doi:10.1194/jlr.C500003-JLR200 on April 1, 2005

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Journal of Lipid Research, Vol. 46, 1093-1096, June 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Rapid Communication

Increased arachidonic acid concentration in the brain of Flinders Sensitive Line rats, an animal model of depression

Pnina Green1,*, Iris Gispan-Herman{dagger} and Gal Yadid{dagger}

* Laboratory for the Study of Fatty Acids, Felsenstein Medical Research Center, Petah Tiqva, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
{dagger} Faculty of Life Sciences and the Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel

Published, JLR Papers in Press, April 1, 2005. DOI 10.1194/jlr.C500003-JLR200

1 To whom correspondence should be addressed. e-mail: pgreen{at}post.tau.ac.il


ABSTRACT

Depression may be associated with impaired membrane PUFA composition, especially decreased n-3 PUFA. This assumption has not been tested at the level of brain tissue. Moreover, most studies were confounded by dietary variability. We examined the FA composition of selected brain areas in an animal model of depression, the Flinders Sensitive Line (FSL) rat, and compared the findings with those in controls fed identical diets. In all brain regions studied, the concentration of arachidonic acid (AA) was significantly higher in the FSL rats: in the hypothalamus by 21%, in the nucleus accumbens by 24%, in the prefrontal cortex by 31%, and in the striatum by 23%. No significant differences were observed for n-3 PUFA or for the saturated and monounsaturated FAs. Our results confirm the existence of altered brain PUFA composition in an animal model of depression. The finding of increased AA, an n-6 PUFA, rather than decreased n-3 PUFA, emphasizes the importance of both PUFA families in the pathophysiological processes underlying depression.

The FSL rat is a useful tool for further elucidation of the FA disturbances in depression.

Abbreviations: AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FAME, fatty acid methyl ester; FSL, Flinders Sensitive Line

Supplementary key words n-6 polyunsaturated fatty acids • n-3 polyunsaturated fatty acids • depression • docosahexaenoic acid • eicosapentaenoic acid


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I. Kan, E. Melamed, D. Offen, and P. Green
Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation
J. Lipid Res., March 1, 2007; 48(3): 513 - 517.
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