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Originally published In Press as doi:10.1194/jlr.M500073-JLR200 on May 16, 2005

Papers In Press, published online ahead of print August 1, 2005
J. Lipid Res., doi:10.1194/jlr.M500073-JLR200
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Journal of Lipid Research, Vol. 46, 1692-1702, August 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains

Joseph P. Jarvis1,*, Jane Kenney-Hunt*, Thomas H. Ehrich*, L. Susan Pletscher*, Clay F. Semenkovich{dagger} and James M. Cheverud*

* Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110
{dagger} Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110

The online version of this article (available at http://www.jlr.org) contains an additional table.

Published, JLR Papers in Press, May 16, 2005. DOI 10.1194/jlr.M500073-JLR200

1 To whom correspondence should be addressed. e-mail: jpjarvis{at}artsci.wustl.edu

Maternal effects on offspring phenotypes occur because mothers in many species provide an environment for their developing young. Although these factors are correctly "environmental" with respect to the offspring genome, their variance may have both a genetic and an environmental basis in the maternal generation. Here, reciprocal crosses between C57BL/6J and 10 LGXSM recombinant inbred (RI) strains were performed, and litters were divided at weaning into high-fat and low-fat dietary treatments. Differences between reciprocal litters were used to measure genetic maternal effects on offspring phenotypes. Nearly all traits, including weekly body weights and adult blood serum traits, show effects indicative of genetic variation in maternal effects across RI strains, allowing the quantitative trait loci involved to be mapped. Although much of the literature on maternal effects relates to early life traits, we detect strong and significant maternal effects on traits measured at adulthood (as much as 10% of the trait variance at 17 or more weeks after weaning).

We also found an interaction affecting adult phenotype between the effects of maternal care between RI strain mothers and C57BL/6J mothers and a later environmental factor (dietary fat intake) for some age-specific weights.

Abbreviations: AUC, area under the curve; QTL, quantitative trait loci; RI, recombinant inbred

Supplementary key words maternal effects • quantitative trait loci • late-onset diseases • genotype-environment interaction


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