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Originally published In Press as doi:10.1194/jlr.E500003-JLR200 on July 1, 2005
Journal of Lipid Research, Vol. 46, 2029-2032, September 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology
A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases
Mary C. Hunt*,
Junji Yamada ,
Lois J. Maltais ,
Mathew W. Wright**,
Ernesto J. Podesta and
Stefan E. H. Alexson*
* Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry C1-74, Karolinska University Hospital at Huddinge, Stockholm, Sweden
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Mouse Genomic Nomenclature Committee, Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME
** University College London, London, UK
 Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.E500003-JLR200
To whom correspondence should be addressed. e-mail: mary.hunt{at}labmed.ki.se
ABSTRACT
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family.
The family root symbol is ACOT, with human genes named ACOT1ACOT12, and rat and mouse genes named Acot1Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.
Supplementary key words fatty acid metabolism coenzyme A peroxisomes

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Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.
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