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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.M600157-JLR200 on August 25, 2006

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Journal of Lipid Research, Vol. 47, 2367-2373, November 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Role of adipose differentiation-related protein in lung surfactant production: a reassessment

Amy L. Magra1,*, Pamela S. Mertz1,*, John S. Torday{dagger} and Constantine Londos2,*

* Membrane Regulation Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8028
{dagger} Departments of Pediatrics and Obstetrics & Gynecology, Harbor-UCLA Medical Center Research and Education Institute, University of California at Los Angeles, Torrance, CA 90502

Published, JLR Papers in Press, August 25, 2006.

1 A. L. Magra and P. S. Mertz contributed equally to this work.

2 To whom correspondence should be addressed. e-mail: deanl{at}intra.niddk.nih.gov

Based on data developed with the use of isolated lipid droplets from neonatal rat lung lipofibroblasts, we speculated previously that the droplet coat protein, adipose differentiation-related protein (ADFP), mediated the transfer of lipids into type 2 lung epithelial cells for the production of surfactant phospholipids. The present studies were designed to test the role of ADFP in this transfer with the use of ADFP-coated lipid droplets from CHO fibroblast cells and a cultured human lung epithelial cell line. We found no role for ADFP in the lipid transfer and conclude that a lipase associated with the lipid droplets hydrolyzes their core triacylglycerols, releasing fatty acids that are taken up by the epithelial cells.

Supplementary key words lipid droplets • surfactant phospholipid • PAT proteins


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