| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Lipid Research, Vol. 47, 2433-2443, November 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98195-6426
Published, JLR Papers in Press, August 10, 2006.
1 To whom correspondence should be addressed. e-mail: smashie{at}u.washington.edu
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor apolipoprotein A-I (apoA-I), whereas ABCG1 and ABCG4 mediate the transport of cholesterol from cells to lipidated lipoproteins. ABCA1, ABCG1, and ABCG4 are all expressed in cholesterol-loaded macrophages, and macrophages from ABCA1 and ABCG1 knockout mice accumulate cholesteryl esters. Here, we show that the lipidated particles generated by incubating cells overexpressing ABCA1 with apoA-I are efficient acceptors for cholesterol released from cells overexpressing either ABCG1 or ABCG4. The cholesterol released to the particles was derived from a cholesterol oxidase-accessible plasma membrane pool in both ABCG1 and ABCG4 cells, which is the same pool of cholesterol shown previously to be removed by high density lipoproteins. ABCA1 cells incubated with apoA-I generated two major populations of cholesterol- and phospholipid-rich lipoprotein particles that were converted by ABCG1 or ABCG4 cells to one major particle population that was highly enriched in cholesterol. These results suggest that ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles.
Supplementary key words ATP binding cassette transporter A1 • ATP binding cassette transporter G1 • ATP binding cassette transporter G4 • high density lipoprotein
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. R. Su, J. L. Blakemore, Y. Zhang, M. F. Linton, and S. Fazio Lentiviral Transduction of ApoAI Into Hematopoietic Progenitor Cells and Macrophages: Applications to Cell Therapy of Atherosclerosis Arterioscler. Thromb. Vasc. Biol., August 1, 2008; 28(8): 1439 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Burgess, P. F. Parkinson, M. M. Racke, V. Hirsch-Reinshagen, J. Fan, C. Wong, S. Stukas, L. Theroux, J. Y. Chan, J. Donkin, et al. ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo J. Lipid Res., June 1, 2008; 49(6): 1254 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mauldin, M. H. Nagelin, A. J. Wojcik, S. Srinivasan, M. D. Skaflen, C. R. Ayers, C. A. McNamara, and C. C. Hedrick Reduced Expression of ATP-Binding Cassette Transporter G1 Increases Cholesterol Accumulation in Macrophages of Patients With Type 2 Diabetes Mellitus Circulation, May 27, 2008; 117(21): 2785 - 2792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, M. Hoekstra, K. Habets, I. Meurs, V. de Waard, R. B. Hildebrand, Y. Wang, G. Chimini, J. Kuiper, T. J.C. Van Berkel, et al. Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels Arterioscler. Thromb. Vasc. Biol., February 1, 2008; 28(2): 258 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Christoffersen, M. Jauhiainen, M. Moser, B. Porse, C. Ehnholm, M. Boesl, B. Dahlback, and L. B. Nielsen Effect of Apolipoprotein M on High Density Lipoprotein Metabolism and Atherosclerosis in Low Density Lipoprotein Receptor Knock-out Mice J. Biol. Chem., January 25, 2008; 283(4): 1839 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Jacobs, S. Lingrell, Y. Zhao, G. A. Francis, and D. E. Vance Hepatic CTP:Phosphocholine Cytidylyltransferase-{alpha} Is a Critical Predictor of Plasma High Density Lipoprotein and Very Low Density Lipoprotein J. Biol. Chem., January 25, 2008; 283(4): 2147 - 2155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Out, W. Jessup, W. Le Goff, M. Hoekstra, I. C. Gelissen, Y. Zhao, L. Kritharides, G. Chimini, J. Kuiper, M. J. Chapman, et al. Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1 Circ. Res., January 4, 2008; 102(1): 113 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Tarr and P. A. Edwards ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 J. Lipid Res., January 1, 2008; 49(1): 169 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Sano, A. Kobayashi, K. Nagao, K. Kumagai, N. Kioka, K. Hanada, K. Ueda, and M. Matsuo Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 J. Lipid Res., November 1, 2007; 48(11): 2377 - 2384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Adorni, F. Zimetti, J. T. Billheimer, N. Wang, D. J. Rader, M. C. Phillips, and G. H. Rothblat The roles of different pathways in the release of cholesterol from macrophages J. Lipid Res., November 1, 2007; 48(11): 2453 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Pagler, A. Neuhofer, H. Laggner, W. Strobl, and H. Stangl Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired J. Lipid Res., October 1, 2007; 48(10): 2141 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kotokorpi, E. Ellis, P. Parini, L.-M. Nilsson, S. Strom, K. R. Steffensen, J.-A. Gustafsson, and A. Mode Physiological Differences between Human and Rat Primary Hepatocytes in Response to Liver X Receptor Activation by 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic Acid Hydrochloride (GW3965) Mol. Pharmacol., October 1, 2007; 72(4): 947 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mulya, J.-Y. Lee, A. K. Gebre, M. J. Thomas, P. L. Colvin, and J. S. Parks Minimal Lipidation of Pre-{beta} HDL by ABCA1 Results in Reduced Ability to Interact with ABCA1 Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-D. Wang, V. Franklin, and Y. L. Marcel In Vivo Reverse Cholesterol Transport From Macrophages Lacking ABCA1 Expression Is Impaired Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1837 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guizzetti, J. Chen, J. F. Oram, R. Tsuji, K. Dao, T. Moller, and L. G. Costa Ethanol Induces Cholesterol Efflux and Up-regulates ATP-binding Cassette Cholesterol Transporters in Fetal Astrocytes J. Biol. Chem., June 29, 2007; 282(26): 18740 - 18749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Yancey, H. Yu, M. F. Linton, and S. Fazio A Pathway-Dependent on ApoE, ApoAI, and ABCA1 Determines Formation of Buoyant High-Density Lipoprotein by Macrophage Foam Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1123 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yvan-Charvet, F. Matsuura, N. Wang, M. J. Bamberger, T. Nguyen, F. Rinninger, X.-C. Jiang, C. L. Shear, and A. R. Tall Inhibition of Cholesteryl Ester Transfer Protein by Torcetrapib Modestly Increases Macrophage Cholesterol Efflux to HDL Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1132 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Kim, A. S. Rahmanto, A. Kamili, K.-A. Rye, G. J. Guillemin, I. C. Gelissen, W. Jessup, A. F. Hill, and B. Garner Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-beta Peptide Generation J. Biol. Chem., February 2, 2007; 282(5): 2851 - 2861. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
