Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.P600005-JLR200 on September 18, 2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
P600005-JLR200v1
47/12/2814    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Erkkilä, A. T.
Right arrow Articles by Lichtenstein, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erkkilä, A. T.
Right arrow Articles by Lichtenstein, A. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 47, 2814-2819, December 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Patient-Oriented Research

Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD

Arja T. Erkkilä1,*, Nirupa R. Matthan{dagger}, David M. Herrington§ and Alice H. Lichtenstein{dagger}

* School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
{dagger} Cardiovascular Nutrition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
§ Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC

Published, JLR Papers in Press, September 18, 2006.

1 To whom correspondence should be addressed. e-mail: arja.erkkila{at}uku.fi


ABSTRACT

Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases {alpha}-linolenic acid (ALA) have been associated with reduced risk of cardiovascular events and death. The association between n-3 fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed among women with established coronary artery disease (CAD). A prospective cohort study involved postmenopausal women (n = 228) participating in the Estrogen Replacement and Atherosclerosis Trial. Quantitative coronary angiography was performed at baseline and after 3.2 ± 0.6 (mean ± SD) years. Women with plasma phospholipid (PL) DHA levels above the median, compared with below, exhibited less atherosclerosis progression, as expressed by decline in minimum coronary artery diameter (–0.04 ± 0.02 and –0.10 ± 0.02 mm, respectively; P = 0.007) or increase in percentage stenosis (1.34 ± 0.76% and 3.75 ± 0.74%, respectively; P = 0.006), and had fewer new lesions [2.0% (0.5–3.5%) of measured segments (95% confidence interval) and 4.2% (2.8–5.6%), respectively; P = 0.009] after adjustments for cardiovascular risk factors. Similar results were observed for DHA in the triglycerides (TGs). EPA and ALA in plasma lipids were not significantly associated with atherosclerosis progression. Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD.

Supplementary key words polyunsaturated fatty acids • eicosapentaenoic acid • angiography • coronary artery disease

Abbreviations: ALA, {alpha}-linolenic acid; CAD, coronary artery disease; CE, cholesteryl ester; CVD, cardiovascular disease; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; PL, phospholipid; TG, triglyceride


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
K. R Motoyama, J D. Curb, T. Kadowaki, A. El-Saed, R. D Abbott, T. Okamura, R. W Evans, Y. Nakamura, K. Sutton-Tyrrell, B. L Rodriquez, et al.
Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men
Am. J. Clinical Nutrition, July 1, 2009; 90(1): 49 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
F. Imamura, P. F Jacques, D. M Herrington, G. E Dallal, and A. H Lichtenstein
Adherence to 2005 Dietary Guidelines for Americans is associated with a reduced progression of coronary artery atherosclerosis in women with established coronary artery disease
Am. J. Clinical Nutrition, July 1, 2009; 90(1): 193 - 201.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. Harris
Omega-3 Fatty Acids: The "Japanese" Factor?
J. Am. Coll. Cardiol., August 5, 2008; 52(6): 425 - 427.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-L. Song, J. A. Lawson, D. Reilly, J. Rokach, C.-T. Chang, B. Giasson, and G. A. FitzGerald
Neurofurans, Novel Indices of Oxidant Stress Derived from Docosahexaenoic Acid
J. Biol. Chem., January 4, 2008; 283(1): 6 - 16.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement