HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: M500359-JLR200v1 47/5/982    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rubin, J. Articles by Berglund, L. Search for Related Content PubMed PubMed Citation Articles by Rubin, J. Articles by Berglund, L. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 47, 982-989, May 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a]

Jill Rubin^*, Han Jo Kim^*, Thomas A. Pearson, Steve Holleran, Rajasekhar Ramakrishnan and Lars Berglund^1,*,**,

^* Department of Medicine, Columbia University, New York, NY
Department of Community and Family Medicine, University of Rochester, Rochester, NY
Department of Pediatrics, Columbia University, New York, NY
^** Department of Medicine, University of California Davis, Davis, CA
Department of Veterans Affairs Northern California Health Care System, Sacramento, CA

Published, JLR Papers in Press, February 22, 2006.

¹ To whom correspondence should be addressed. e-mail: lars.berglund{at}ucdmc.ucdavis.edu

Apolipoprotein [a] (apo[a]) gene size is a major predictor of lipoprotein [a] level. To determine genetic predictors of allele-specific apo[a] levels beyond gene size, we evaluated the upstream C/T and pentanucleotide repeat (PNR) polymorphisms. We determined apo[a] sizes, allele-specific apo[a] levels, and C/T and PNR in 215 Caucasians and 139 African Americans. For Caucasians, apo[a] size affected allele-specific levels substantially greater in subjects with apo[a] < 24 K4; for African Americans, the size effect was smaller than in Caucasians, <24 K4, but did not decrease at higher repeats. In both groups, the level decreased with increasing size of the other allele. Controlling for apo[a] sizes, PNR decreased allele-specific apo[a] levels in Caucasians with increasing PNR > 8. In a multiple regression model, apo[a] allele size and size and expression of the other apo[a] allele (and PNR > 8 for Caucasians) significantly predicted allele-specific apo[a] levels. For a common PNR 8 allele, predicted values were similar in the two ethnicities for small size apo[a]. Allele-specific apo[a] levels were influenced by the other allele size and expression. Observed differences between Caucasians and African Americans in allele-specific apo[a] levels were explained for small apo[a] sizes by the other allele size and PNR; the ethnicity differences remain unexplained for larger sizes.

Supplementary key words lipoprotein [a] • African Americans • genotyping • polymorphism • apolipoprotein [a] • pentanucleotide repeat

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Ober, A. S. Nord, E. E. Thompson, L. Pan, Z. Tan, D. Cusanovich, Y. Sun, R. Nicolae, C. Edelstein, D. H. Schneider, et al. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q J. Lipid Res., May 1, 2009; 50(5): 798 - 806. [Abstract] [Full Text] [PDF]

				E. Anuurad, J. Rubin, A. Chiem, R. P. Tracy, T. A. Pearson, and L. Berglund High Levels of Inflammatory Biomarkers Are Associated with Increased Allele-Specific Apolipoprotein(a) Levels in African-Americans J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1482 - 1488. [Abstract] [Full Text] [PDF]

				E. Anuurad, G. Lu, J. Rubin, T. A. Pearson, and L. Berglund ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study J. Lipid Res., March 1, 2007; 48(3): 693 - 698. [Abstract] [Full Text] [PDF]

				E. Anuurad, J. Rubin, G. Lu, T. A. Pearson, S. Holleran, R. Ramakrishnan, and L. Berglund Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol J. Lipid Res., November 1, 2006; 47(11): 2475 - 2481. [Abstract] [Full Text] [PDF]