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Journal of Lipid Research, Vol. 47, 1733-1738, August 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Absence of VLDL secretion does not affect -tocopherol content in peripheral tissues

Kaori Minehira-Castelli^1,*, Scott W. Leonard, Quinn M. Walker, Maret G. Traber and Stephen G. Young^2,

^* Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331
Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095

Published, JLR Papers in Press, May 18, 2006.

¹ Present address of K. Minehira-Castelli: Institute of Physiology and Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.

² To whom correspondence should be addressed. e-mail: sgyoung{at}mednet.ucla.edu

-Tocopherol is a lipid-soluble antioxidant that helps to prevent oxidative damage to cellular lipids. -Tocopherol is absorbed by the intestine and is taken up and retained by the liver; it is widely presumed that -tocopherol is then delivered to peripheral tissues by the secretion of VLDL. To determine whether VLDL secretion is truly important for the delivery of -tocopherol to peripheral tissues, we examined -tocopherol metabolism in mice that lack microsomal triglyceride transfer protein (Mttp) expression in the liver and therefore cannot secrete VLDL (Mttp^/ mice). Mttp^/ mice have low plasma lipid levels and increased stores of lipids in the liver. Similarly, -tocopherol levels in the plasma were lower in Mttp^/ mice than in controls, whereas hepatic -tocopherol stores were higher. However, -tocopherol levels in the peripheral tissues of Mttp^/ mice were nearly identical to those of control mice, suggesting that VLDL secretion is not critical for the delivery of -tocopherol to peripheral tissues. When fed a diet containing deuterated -tocopherol, Mttp^/ and control mice had similar incorporation of deuterated -tocopherol into plasma and various peripheral tissues. We conclude that the absence of VLDL secretion has little effect on the stores of -tocopherol in peripheral tissues, at least in the mouse.

Supplementary key words -tocopherol • microsomal triglyceride transfer protein • vitamin E

Abbreviations: apoB, apolipoprotein B; Mttp, microsomal triglyceride transfer protein; pI-pC, polyinosinic-polycytidylic ribonucleic acid; -TTP, -tocopherol transfer protein

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