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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.R600020-JLR200 on July 11, 2006

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Journal of Lipid Research, Vol. 47, 1891-1907, September 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Thematic Review

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Approaches to lipid metabolism gene identification and characterization in the postgenomic era

Karen Reue1 and Laurent Vergnes

Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, and Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073

Published, JLR Papers in Press, July 11, 2006.

1 To whom correspondence should be addressed. e-mail: reuek{at}ucla.edu

The availability of genomic resources has already had a tremendous impact on biomedical research. In this review, we describe how whole genome sequence and high-throughput functional genomics projects have facilitated the identification and characterization of important genes in lipid metabolism and disease. We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future.

Supplementary key words comparative genomics • positional cloning • functional genomics • gene-trap mutagenesis • ethylnitrosourea mutagenesis


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