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Originally published In Press as doi:10.1194/jlr.M600108-JLR200 on June 1, 2006

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Journal of Lipid Research, Vol. 47, 1908-1914, September 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases

Yaomin Hu, Wei Liu1, Rong Huang and Xiaoying Zhang

Division of Endocrinology, Department of Internal Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai 200127, China

Published, JLR Papers in Press, June 1, 2006.

1 To whom correspondence should be addressed. e-mail: Amin99{at}163.com

This systematic review attempted to summarize the associations between the Asn291Ser variant in the lipoprotein lipase (LPL) gene and dyslipidemia, the risk of type 2 diabetes mellitus (T2DM), and coronary heart disease (CHD). In addition, the relationships between the Asn291Ser variant and other metabolic diseases such as obesity and high blood pressure were also investigated in this systematic review. We systematically reviewed the literature by means of a meta-analysis. Twenty-one articles, including 19,246 white subjects, were selected for this meta-analysis. The summary standardized mean difference (SMD) of plasma triglyceride (TG) for carriers compared with noncarriers of the Asn291Ser variant was 3.23 (P < 0.00001). The summary SMD of plasma HDL-cholsterol (HDL-C) for carriers compared with noncarriers of the Asn291Ser variant was –3.42 (P < 0.0001). The summary SMD of the association of the Asn291Ser variant with plasma TG increased with increasing age and weight gain. Significant interactions between the LPL Asn291Ser variant and fasting glucose, T2DM, and CHD were seen (P = 0.02, 0.04, and 0.01, respectively). No significant interactions were seen between the LPL Asn291Ser variant and body mass index, waist–hip ratio, and blood pressure (P > 0.05). This meta-analysis indicates that the Asn291Ser variant in the LPL gene is a risk factor for dyslipidemia, characterized by hypertriglyceridemia and low HDL-C levels. And the Asn291Ser variant in the LPL gene predisposes to more severe dyslipidemia with increasing age and weight gain. Also, this meta-analysis shows that the LPL Asn291Ser variant is associated with CHD and T2DM.

Supplementary key words dyslipidemia • type 2 diabetes mellitus • coronary heart disease • obesity • high blood pressure

Abbreviations: BMI, body mass index; CHD, coronary heart disease; HBP, high blood pressure; HDL-C, HDL-cholesterol; LPL, lipoprotein lipase; PL, pancreatic lipase; SMD, standardized mean difference; T2DM, type 2 diabetes mellitus; TG, triglyceride; WHR, waist–hip ratio


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