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Journal of Lipid Research, Vol. 47, 2055-2063, September 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs

Chi Zhang^*,,, Weidong Yin^1,*,, Duanfang Liao^**, Liang Huang, Chaoke Tang^*, Kazuhiko Tsutsumi, Zongbao Wang, Yi Liu, Qinkai Li, Hongjie Hou, Manbo Cai and Junxia Xiao

^* Institute of Cardiovascular Research, Nanhua University Medical School, Hengyang, Hunan 421001, China
Department of Biochemistry and Molecular Biology, Nanhua University School of Life Sciences and Technology, Hengyang, Hunan 421001, China
Function Laboratory Center, Nanhua University Medical School, Hengyang, Hunan 421001, China
^** Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang, Hunan 421001, China
Department of Operative Surgery, Nanhua University Medical School, Hengyang, Hunan 421001, China
Research and Development, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan

Published, JLR Papers in Press, June 28, 2006.

¹ To whom correspondence should be addressed: e-mail wdy20012001{at}yahoo.com

It is widely believed that high density lipoprotein-cholesterol (HDL-C) functions to transport cholesterol from peripheral cells to the liver by reverse cholesterol transport (RCT), a pathway that may protect against atherosclerosis by clearing excess cholesterol from arterial cells. A cellular ATP binding cassette transporter called ABCA1 mediates the first step of RCT. NO-1886 has been proven to be highly effective at increasing HDL-C and reducing atherosclerosis. However, the mechanism of atherosclerosis inhibition for NO-1886 is not fully understood. In this study, the effects of NO-1886 on ABCA1 were investigated in high-fat/high-sucrose/high-cholesterol-fed Chinese Bama minipigs. Administration of NO-1886 (0.1 g/kg body weight/day) in the diet for 5 months significantly reduced atherosclerosis lesions and significantly increased plasma HDL-C and apolipoprotein A-I levels. The mRNA and protein levels of ABCA1 in the liver, retroperitoneal adipose tissue, and aorta were increased by NO-1886 as well. Multivariate linear regression analysis showed that the levels of LPL in plasma and the levels of ABCA1 in aorta were independently associated with the atherosclerotic lesion area. In addition, NO-1886 upregulated liver X receptor and affected the expression of scavenger receptor class B type I in the liver. These results demonstrate that the mechanism of atherosclerosis inhibition for NO-1886 is associated with its effect on ABCA1.

Supplementary key words liver X receptor • scavenger receptor class B type I • [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]phosphonic acid diethyl ester

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