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Originally published In Press as doi:10.1194/jlr.R600027-JLR200 on October 25, 2006

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Journal of Lipid Research, Vol. 48, 1-8, January 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Thematic Review

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Proteomics approaches to the systems biology of cardiovascular diseases

Thomas A. Drake1,* and Peipei Ping{dagger},§

* Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
{dagger} Department of Physiology, University of California Los Angeles, Los Angeles, CA
§ Department of Medicine, University of California Los Angeles, Los Angeles, CA

Published, JLR Papers in Press, October 25, 2006.

1 To whom correspondence should be addressed. e-mail: tdrake{at}mednet.ucla.edu

Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies used, present examples of how these are currently being used in the systems biology context, and discuss future directions.

Supplementary key words biomarker • mass spectrometry • network


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