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Journal of Lipid Research, Vol. 48, 218-225, January 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Patient-Oriented Research

High postprandial triglyceridemia in patients with type 2 diabetes and microalbuminuria

Nicholas Tentolouris^1,*, Andreas Stylianou^*, Evangelia Lourida, Despoina Perrea^*, Despoina Kyriaki^*, Eleni C. Papavasiliou, Alexandros D. Tselepis and Nicholas Katsilambros^*

^* First Department of Propaedeutic Medicine, Laiko Hospital, Athens University Medical School, Athens, Greece
Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

Published, JLR Papers in Press, October 3, 2006.

¹ To whom correspondence should be addressed. e-mail: ntentol{at}med.uoa.gr

ABSTRACT

Microalbuminuria (MA) is an independent risk factor for atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Postprandial lipemia is also associated with excess cardiovascular risk. However, the association between MA and postprandial lipemia in diabetes has not been investigated. A total of 64 patients with T2DM, 30 with and 34 without MA, were examined. Plasma total triglycerides (TGs), triglycerides contained in chylomicrons (CM-TG), and TGs in CM-deficient plasma were measured at baseline and every 2 h for 6 h after a mixed meal. Postheparin LPL and HL activities were also determined. Plasma levels of apolipoprotein A-V (apoA-V), apoC-II, and apoC-III were measured in the fasting state and 2 h postprandially. Patients with MA had higher postprandial total TG levels than those without MA (P < 0.001); this increase been attributed mainly to CM-TG. LPL activity and fasting concentrations of the measured apolipoproteins were not different between the studied groups, whereas HL activity was higher in the patients with MA. ApoC-II and apoC-III levels did not change postprandially in either study group, whereas apoA-V increased more in the patients with MA. These data demonstrate for the first time that MA is characterized by increased postprandial lipemia in patients with T2DM and may explain in part the excess cardiovascular risk in these patients.

Supplementary key words triglycerides • lipoprotein lipase • hepatic lipase • apolipoprotein C-II • apolipoprotein C-III • apolipoprotein A-V • postprandial lipemia

Abbreviations: AER, albumin excretion rate; apoA-V, apolipoprotein A-V; AUC, area under the curve; BMI, body mass index; CM, chylomicron; CM-TG, triglycerides in chylomicron fraction; HOMA-IR, homeostasis model assessment equation insulin resistance; MA, microalbuminuria; MS, metabolic syndrome; T2DM, type 2 diabetes mellitus; TG, triglyceride; WHR, waist-to-hip ratio

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