J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.R700009-JLR200 on May 16, 2007 Originally published In Press as doi:10.1194/jlr.R700009-JLR200 on May 11, 2007

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
R700009-JLR200v1
R700009-JLR200v2
48/10/2103    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pilch, P. F.
Right arrow Articles by Gygi, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pilch, P. F.
Right arrow Articles by Gygi, S. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Lipid Research, Vol. 48, 2103-2111, October 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Thematic Review

Cellular spelunking: exploring adipocyte caveolae

Paul F. Pilch1,*, Ricardo P. Souto2,*, Libin Liu*, Mark P. Jedrychowski*,{dagger}, Eric A. Berg*,§, Catherine E. Costello*,§ and Steven P. Gygi{dagger}

* Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118
§ Department of Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA 02118
{dagger} Department of Cell Biology, Harvard Medical School, Boston, MA 02115

Published, JLR Papers in Press, May 16, 2007.

2 Current address of R. P. Souto: Faculdade de Medicina do ABC, Santo Andre, SP, Brazil, and Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

1 To whom correspondence should be addressed. e-mail: ppilch{at}bu.edu

It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the topic that describe various, sometimes contradictory, caveolae functions. Here, we review the field from an "adipocentric" point of view and suggest that caveolae may have a function of particular use for the fat cell, namely the modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways, and it will require further experimental scrutiny to resolve controversies surrounding these possible activities.

Supplementary key words caveolin • cavin • fatty acid • uptake • proteomics


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. Liu and P. F. Pilch
A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization
J. Biol. Chem., February 15, 2008; 283(7): 4314 - 4322.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.