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Journal of Lipid Research, Vol. 48, 2103-2111, October 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Thematic Review

Cellular spelunking: exploring adipocyte caveolae

Paul F. Pilch^1,*, Ricardo P. Souto^2,*, Libin Liu^*, Mark P. Jedrychowski^*,, Eric A. Berg^*,, Catherine E. Costello^*, and Steven P. Gygi

^* Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118
Department of Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA 02118
Department of Cell Biology, Harvard Medical School, Boston, MA 02115

Published, JLR Papers in Press, May 16, 2007.

² Current address of R. P. Souto: Faculdade de Medicina do ABC, Santo Andre, SP, Brazil, and Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

¹ To whom correspondence should be addressed. e-mail: ppilch{at}bu.edu

It has been known for decades that the adipocyte cell surface is particularly rich in small invaginations we now know to be caveolae. These structures are common to many cell types but are not ubiquitous. They have generated considerable curiosity, as manifested by the numerous publications on the topic that describe various, sometimes contradictory, caveolae functions. Here, we review the field from an "adipocentric" point of view and suggest that caveolae may have a function of particular use for the fat cell, namely the modulation of fatty acid flux across the plasma membrane. Other functions for adipocyte caveolae that have been postulated include participation in signal transduction and membrane trafficking pathways, and it will require further experimental scrutiny to resolve controversies surrounding these possible activities.

Supplementary key words caveolin • cavin • fatty acid • uptake • proteomics

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