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Originally published In Press as doi:10.1194/jlr.M700317-JLR200 on August 16, 2007

Papers In Press, published online ahead of print November 1, 2007
J. Lipid Res., doi:10.1194/jlr.M700317-JLR200
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Journal of Lipid Research, Vol. 48, 2471-2477, November 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid compositionboxs

Ken D. Stark*, Sun-Young Lim{dagger} and Norman Salem, Jr.1,§

* Laboratory of Nutritional and Nutraceutical Research, Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
{dagger} Division of Marine Environment and Bioscience, Korea Maritime University, Busan 606-791, Korea
§ Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892

boxs The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of 9 tables.

Published, JLR Papers in Press, August 16, 2007.

1 To whom correspondence should be addressed. e-mail: nsalem{at}niaaa.nih.gov

Docosahexaenoic acid (DHA; 22:6n-3) and n-6 docosapentaenoic acid (DPAn-6; 22:5n-6) are components of enriched animal feed and oil derived from Schizochytrium species microalgae. A one generation, artificial rearing model from day 2 after birth onward (AR) and a dam-reared control group (DAM) were used to examine DPAn-6 feeding on the fatty acid composition of various rat tissues at 15 weeks of age. Four AR diets were based on an n-3 fatty acid-deficient, 18:2n-6-based artificial milk with 22:6n-3 and/or 22:5n-6 added: AR-LA, AR-DHA, AR-DPAn-6, and AR-DHA+DPAn-6. The 22:6n-3 levels for the DAM, AR-DHA, and AR-DHA+DPAn-6 groups tended to be similar and higher than in the AR-LA and AR-DPAn-6 groups. The levels of 22:5n-6 tended to be higher only in the absence of dietary 22:6n-3. Adipose levels of 22:5n-6 was the only exception, as 22:5n-6 was significantly higher in AR-DHA+DPAn-6 than was observed in either the DAM or the AR-DHA group. There were no differences in 20:4n-6 levels within the tissues examined. In conclusion, 22:5n-6 replaces 22:6n-3 in the absence of 22:6n-3 only and does not appear to compete with 22:6n-3 in the presence of dietary 22:6n-3, suggesting that oils containing 22:5n-6 and 22:6n-3 may be a good dietary source of 22:6n-3.

Supplementary key words brain • heart • plasma • erythrocytes • liver • adipose • kidney • muscle • testes • gas chromatography

Abbreviations: AR, artificially reared; DAM, dam-reared; DHA, docosahexaenoic acid; DPAn-6, n-6 docosapentaenoic acid; HUFA, highly unsaturated fatty acid; LA, linoleic acid


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