J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.P700023-JLR200 on August 2, 2007 Originally published In Press as doi:10.1194/jlr.P700023-JLR200 on July 30, 2007

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
P700023-JLR200v1
P700023-JLR200v2
48/11/2485    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goodenowe, D. B.
Right arrow Articles by Wood, P. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goodenowe, D. B.
Right arrow Articles by Wood, P. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 48, 2485-2498, November 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

Dayan B. Goodenowe1,*, Lisa L. Cook*, Jun Liu*, Yingshen Lu*, Dushmanthi A. Jayasinghe*, Pearson W. K. Ahiahonu*, Doug Heath*, Yasuyo Yamazaki*, John Flax{dagger}, Kevin F. Krenitsky§, D. L. Sparks**, Alan Lerner{dagger}{dagger}, Robert P. Friedland{dagger}{dagger}, Takashi Kudo§§, Kouzin Kamino§§,***, Takashi Morihara§§, Masatoshi Takeda§§ and Paul L. Wood{dagger}{dagger}{dagger}

* Phenomenome Discoveries, Inc., Saskatoon, Saskatchewan, Canada
{dagger} PrecisionMed, Inc., San Diego, CA
§ Bioserve, Inc., Boston, MA
** Sun Health Research Institute, Sun City, AZ
{dagger}{dagger} Case Western Reserve University, Cleveland, OH
§§ Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
*** Shoraiso National Hospital, Nara, Japan
{dagger}{dagger}{dagger} Falk Center for Molecular Therapeutics, Northwestern University, Chicago, IL

Published, JLR Papers in Press, August 2, 2007.

1 To whom correspondence should be addressed. e-mail: d.goodenowe{at}phenomenome.com


ABSTRACT

Although dementia of the Alzheimer's type (DAT) is the most common form of dementia, the severity of dementia is only weakly correlated with DAT pathology. In contrast, postmortem measurements of cholinergic function and membrane ethanolamine plasmalogen (PlsEtn) content in the cortex and hippocampus correlate with the severity of dementia in DAT. Currently, the largest risk factor for DAT is age. Because the synthesis of PlsEtn occurs via a single nonredundant peroxisomal pathway that has been shown to decrease with age and PlsEtn is decreased in the DAT brain, we investigated potential relationships between serum PlsEtn levels, dementia severity, and DAT pathology. In total, serum PlsEtn levels were measured in five independent population collections comprising >400 clinically demented and >350 nondemented subjects. Circulating PlsEtn levels were observed to be significantly decreased in serum from clinically and pathologically diagnosed DAT subjects at all stages of dementia, and the severity of this decrease correlated with the severity of dementia. Furthermore, a linear regression model predicted that serum PlsEtn levels decrease years before clinical symptoms. The putative roles that PlsEtn biochemistry play in the etiology of cholinergic degeneration, amyloid accumulation, and dementia are discussed.

Supplementary key words aging • peroxisome • neurodegeneration • amyloid

Abbreviations: PtdCho, phosphatidylcholine


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.