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Journal of Lipid Research, Vol. 48, 2499-2505, November 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese

Kuo-Liong Chien^1,*,,, Hsiu-Ching Hsu, Ta-Chen Su, Ming-Fong Chen, Yuan-Teh Lee^1,,** and Frank B. Hu

^* Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Department of Nutrition, School of Public Health, Harvard University, Boston, MA
^** Ming-Shen Medical Center, Taoyuang, Taiwan

Published, JLR Papers in Press, August 13, 2007.

¹ To whom correspondence should be addressed. e-mail: klchien{at}ha.mc.ntu.edu.tw (K-L.C.); ytlee{at}ha.mc.ntu.edu.tw (Y-T.L.)

ABSTRACT

The aim of our study was to compare apolipoprotein B (apoB), non-high density lipoprotein cholesterol (nonHDL-C), low density lipoprotein cholesterol (LDL-C), and other lipid markers as predictors of coronary heart disease (CHD) in Chinese. Overall, 122 individuals developed CHD during a median 13.6 years of follow-up in 3,568 adult participants from a community-based cohort. The multivariate relative risk of CHD in the highest quintile compared with the lowest quintile was 2.74 [95% confidence interval (CI), 1.45–5.19] for apoB, 1.98 (95% CI, 1.00–3.92) for nonHDL-C, and 1.86 (95% CI, 1.00–3.49) for LDL-C (all tests for trend, P < 0.05). ApoB also had the highest receiver operator characteristic curve area (0.63; 95% CI, 0.58–0.68) in predicting CHD. When apoB and nonHDL-C were mutually adjusted, only apoB was predictive; the relative risk was 2.80 (95% CI, 1.31–5.96; P = 0.001) compared with 1.09 (95% CI, 0.49–2.40; P = 0.75) for nonHDL-C. Compared with the lowest risk, participants with the highest apoB and total cholesterol/HDL-C had a 3-fold increased risk of developing CHD (relative risk = 3.21; 95% CI, 1.45–7.14). These data provide strong evidence that apoB concentration was a better predictor of CHD than other lipid markers in Chinese.

Supplementary key words lipids • lipoproteins • apolipoproteins • risk factors

Abbreviations: apoB, apolipoprotein B; CHD, coronary heart disease; LDL-C, low density lipoprotein cholesterol; nonHDL-C, non-high density lipoprotein cholesterol; ROC, receiver operator characteristic; TC, total cholesterol; TG, triglyceride

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