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Originally published In Press as doi:10.1194/jlr.M700213-JLR200 on August 13, 2007

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Journal of Lipid Research, Vol. 48, 2499-2505, November 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese

Kuo-Liong Chien1,*,{dagger},§, Hsiu-Ching Hsu{dagger}, Ta-Chen Su{dagger}, Ming-Fong Chen{dagger}, Yuan-Teh Lee1,{dagger},** and Frank B. Hu§

* Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
{dagger} Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
§ Department of Nutrition, School of Public Health, Harvard University, Boston, MA
** Ming-Shen Medical Center, Taoyuang, Taiwan

Published, JLR Papers in Press, August 13, 2007.

1 To whom correspondence should be addressed. e-mail: klchien{at}ha.mc.ntu.edu.tw (K-L.C.); ytlee{at}ha.mc.ntu.edu.tw (Y-T.L.)


ABSTRACT

The aim of our study was to compare apolipoprotein B (apoB), non-high density lipoprotein cholesterol (nonHDL-C), low density lipoprotein cholesterol (LDL-C), and other lipid markers as predictors of coronary heart disease (CHD) in Chinese. Overall, 122 individuals developed CHD during a median 13.6 years of follow-up in 3,568 adult participants from a community-based cohort. The multivariate relative risk of CHD in the highest quintile compared with the lowest quintile was 2.74 [95% confidence interval (CI), 1.45–5.19] for apoB, 1.98 (95% CI, 1.00–3.92) for nonHDL-C, and 1.86 (95% CI, 1.00–3.49) for LDL-C (all tests for trend, P < 0.05). ApoB also had the highest receiver operator characteristic curve area (0.63; 95% CI, 0.58–0.68) in predicting CHD. When apoB and nonHDL-C were mutually adjusted, only apoB was predictive; the relative risk was 2.80 (95% CI, 1.31–5.96; P = 0.001) compared with 1.09 (95% CI, 0.49–2.40; P = 0.75) for nonHDL-C. Compared with the lowest risk, participants with the highest apoB and total cholesterol/HDL-C had a 3-fold increased risk of developing CHD (relative risk = 3.21; 95% CI, 1.45–7.14). These data provide strong evidence that apoB concentration was a better predictor of CHD than other lipid markers in Chinese.

Supplementary key words lipids • lipoproteins • apolipoproteins • risk factors

Abbreviations: apoB, apolipoprotein B; CHD, coronary heart disease; LDL-C, low density lipoprotein cholesterol; nonHDL-C, non-high density lipoprotein cholesterol; ROC, receiver operator characteristic; TC, total cholesterol; TG, triglyceride


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