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Originally published In Press as doi:10.1194/jlr.M600487-JLR200 on January 27, 2007

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Journal of Lipid Research, Vol. 48, 863-868, April 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Retroperitoneal white adipose tissue lipoprotein lipase activity is rapidly down-regulated in response to acute stress

Albert Casanovas, Núria Parramon, Ferran de la Cruz, Olga Andrés, José Terencio, M. Dolores López-Tejero and Miquel Llobera1

Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain

Published, JLR Papers in Press, January 27, 2007.

1 To whom correspondence should be addressed. e-mail: millobera{at}ub.edu

Tissue-specific regulation of LPL has been widely studied in rats. Previous studies reported that in vivo administration of adrenaline and acute stress cause an increase in plasma LPL activity coinciding with a decrease in white adipose tissue (WAT) LPL activity. We studied the speed of LPL activity changes during 30 min of stress by immobilization (IMMO) in rats. A first experimental approach in permanently cannulated rats permitted sequential blood sampling in the same animal during IMMO and the obtaining of hemodynamic parameters. In a second experimental approach, animals were euthanized at different times after the start of IMMO to determine LPL activity in tissues. Stress was characterized by rises in blood pressure, heart rate, plasma corticosterone, and available circulating energy substrates. Five min after the start of IMMO, LPL activity fell in retroperitoneal WAT and increased in plasma. These data show the quickest LPL activity change ever described in response to a physiological situation. The speed and simultaneity of these changes suggest that the release from endothelium to the bloodstream may constitute a fast nonexplored mechanism of tissue LPL activity regulation, involved in the lipid energy-substrate redistribution between tissues needed to prepare the "fight-or-flight" response.

Supplementary key words plasma • fight-or-flight • rat • immobilization • blood pressure • heart rate

Abbreviations: IMMO, immobilization; rWAT, retroperitoneal white adipose tissue; TAG, triacylglyceride; WAT, white adipose tissue


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Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.