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Originally published In Press as doi:10.1194/jlr.M600323-JLR200 on February 1, 2007

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Journal of Lipid Research, Vol. 48, 1045-1051, May 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Detailed characterization of the lipid A fraction from the nonpathogen Acinetobacter radioresistens strain S13

Serena Leone*, Luisa Sturiale{dagger}, Enrica Pessione§, Roberto Mazzoli§, Carlo Giunta§, Rosa Lanzetta*, Domenico Garozzo{dagger}, Antonio Molinaro1,* and Michelangelo Parrilli*

* Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli "Federico II," I-80126 Napoli, Italy
{dagger} Istituto di Chimica e Tecnologia dei Polimeri, Consiglio Nazionale delle Richerche, I-95123 Catania, Italy
§ Dipartimento di Biologia Animale e dell'Uomo, Università di Torino, I-10123 Torino, Italy

Published, JLR Papers in Press, February 1, 2007.

1 To whom correspondence should be addressed. e-mail: molinaro{at}unina.it

The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological states in debilitated and hospitalized patients. The involvement of lipopolysaccharides (LPSs) as virulence factors in infections by Acinetobacter has been proven, and ongoing studies are aimed toward the complete serological characterization of the O-polysaccharides from LPSs isolated in clinical samples. Conversely, no characterization of the lipid A fraction from Acinetobacter strains has been performed. Here, the detailed structure of the lipid A fraction from A. radioresistens S13 is reported for the first time. A. radioresistens strains have never been isolated in cases of infectious disease. Nevertheless, it is known that the lipid A structure, with minor variations, is highly conserved across the genus; thus, structural details acquired from studies of this nonpathogen strain represent a useful basis for further studies of pathogen species.

Supplementary key words lipopolysaccharide • matrix-assisted laser-desorption ionization mass spectrometry • fatty acid


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