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Journal of Lipid Research, Vol. 48, 1402-1408, June 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Patient-Oriented Research

Peroxisome proliferator-activated receptor polymorphisms and postprandial lipemia in healthy men

Toshiko Tanaka^1,*, Jose M. Ordovas^*, Javier Delgado-Lista, Francisco Perez-Jimenez, Carmen Marin, Pablo Perez-Martinez, Purificacion Gomez and Jose Lopez-Miranda

^* Nutrition and Genomics Laboratory, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
Hospital Universitario Reina Sofia, Unidad de Lipidos y Arteriosclerosis, Cordoba, Spain

Published, JLR Papers in Press, March 15, 2007.

¹ To whom correspondence should be addressed. e-mail: toshiko.tanaka{at}tufts.edu

ABSTRACT

Peroxisome proliferator-activated receptor (PPAR) is a ligand-dependent transcription factor that plays a key role in lipid and glucose homeostasis. This study evaluated whether variants of PPAR are associated with postprandial lipemia. Subjects were given a single fat load composed of 60% calories as fat, 15% as protein, and 25% as carbohydrate. Blood was drawn every hour from baseline to 6 h, then every 2.5 h to 11 h to determine triglyceride (TG) levels. The minor allele of the nonsynonymous p.Leu162Val variant was associated with higher fasting total cholesterol, LDL-cholesterol, and apolipoprotein B. There were no significant associations with all of the postprandial parameters examined. Conversely, the noncoding variant c.140+5435T>C was not associated with fasting lipid concentrations but was significantly associated with decreased postprandial TG and cholesterol in the small TG-rich lipoprotein particle. Although the minor allele carriers displayed lower mean concentrations of TG and cholesterol throughout the postprandial period, the differences were most pronounced in the latter period. These data suggest that PPAR variants may modulate the risk of cardiovascular disease by influencing both fasting and postprandial lipid concentrations.

Supplementary key words triglycerides • fat load • cardiovascular disease • triglyceride-rich lipoproteins

Abbreviations: apoB, apolipoprotein B; AUC, area under the curve; CVD, cardiovascular disease; LDL-C, low density lipoprotein-cholesterol; PPAR, peroxisome proliferator-activated receptor ; SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglyceride; TRL, triglyceride-rich lipoprotein

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