HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: M600513-JLR200v1 48/7/1550    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schäfer, C. Articles by Winkler, K. Search for Related Content PubMed PubMed Citation Articles by Schäfer, C. Articles by Winkler, K. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 48, 1550-1558, July 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL₃ to HDL₂ in alcohol consumers

Christian Schäfer^1,*, Alexandr Parlesak, Joachim Eckoldt, Christiane Bode, Johann Christian Bode^*, Winfried März and Karl Winkler^**

^* Division of Gastroenterology, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany
Department of Physiology of Nutrition, Hohenheim University, Stuttgart, Germany
Synlab Center of Laboratory Diagnostics, Heidelberg, Germany
^** Department of Medicine, University of Freiburg, Freiburg, Germany

Published, JLR Papers in Press, April 12, 2007.

¹ To whom correspondence should be addressed. e-mail: christian.schaefer{at}rbk.de

The reduction of cardiovascular mortality associated with moderate alcohol consumption is chiefly thought to be mediated by an increase of high density lipoprotein cholesterol (HDL-CH). This study highlights additional qualitative changes of HDL that might augment this antiatherogenic effect. In 279 healthy men, alcohol and nutrient consumption were evaluated. Groups 1 (n = 62), 2 (n = 172), and 3 (n = 45) comprised subjects with alcohol consumption of 0–5.0, 5.1–30.0, and 30.1–75 g/day, respectively. Lipid analysis was performed in nonfractionated and fractionated plasma, including subfractions HDL_2a, HDL_2b, and HDL₃. No difference in LDL-cholesterol was observed. Compared with group 1, groups 2 and 3 exhibited significant increases of HDL-CH (group 1, 44 ± 10 mg/dl; group 2, 51 ± 11 mg/dl; group 3, 55 ± 11 mg/dl; mean ± SD, P < 0.0005), accompanied by enhanced lipidation of HDL (increase of the HDL₂-CH/HDL₃-CH ratio). Moreover, phospholipid enrichment of HDL occurred in alcohol consumers, whereas the ratios between other HDL components remained constant. Multivariate analysis revealed alcohol to have the foremost statistical influence on changes of the HDL fraction, followed by body mass index and physical activity level. The increased lipidation of HDL found in alcohol consumers might augment the antiatherogenic effect of HDL-CH increase. In addition, the phospholipid enrichment of HDL might reduce the inflammatory response of atherogenesis.

Supplementary key words low density lipoprotein • very low density lipoprotein • high density lipoprotein 2 • high density lipoprotein 3 • triglycerides • beer • wine • body mass index • apolipoprotein

Abbreviations: apoA-I, apolipoprotein A-I; BMI, body mass index; CE, cholesteryl ester; CETP, cholesteryl ester transfer protein; FC, free cholesterol; HDL-CH, high density lipoprotein-cholesterol; LDL-CH, low density lipoprotein-cholesterol; PAL, physical activity level; PL, phospholipid; PLTP, phospholipid transfer protein; SM, sphingomyelin; TG, triglyceride

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?