HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Papers In Press, published online ahead of print October 1, 2008
J. Lipid Res., doi:10.1194/jlr.M800194-JLR200

This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: M800194-JLR200v1 49/10/2169    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Åberg, K. Articles by McGarvey, S. T. PubMed PubMed Citation Articles by Åberg, K. Articles by McGarvey, S. T. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 49, 2169-2178, October 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands^*,

Karolina Åberg^*, Feng Dai^1,, Guangyun Sun, Ember Keighley^**, Subba Rao Indugula, Linda Bausserman^**, Satupaitea Viali, John Tuitele, Ranjan Deka, Daniel E. Weeks^*, and Stephen T. McGarvey^2,**

^* Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, OH
^** International Health Institute, Brown University, Providence, RI
Ministry of Health, Apia, Samoa
Department of Health, Pago Pago, American Samoa

^* Our work is supported by National Institutes of Health Grant R01 DK-59642 (S.T.M.). K.Å. is supported by the Swedish Research Council.

The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of two figures and one table.

Published, JLR Papers in Press, July 1, 2008.

¹ Present address of F. Dai: Department of Anesthesiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.

² To whom correspondence should be addressed. e-mail: stephen_mcgarvey{at}brown.edu

Abnormal lipid levels are important risk factors for cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing total cholesterol (TC), LDL, HDL and triglyceride in families residing in American Samoa and Samoa as well as in a combined sample from the two polities. We adjusted the traits for a number of environmental covariates, such as smoking, alcohol consumption, physical activity, and material lifestyle. We found suggestive univariate linkage with log of the odds (LOD) scores > 3 for LDL on 6p21-p12 (LOD 3.13) in Samoa and on 12q21-q23 (LOD 3.07) in American Samoa. Furthermore, in American Samoa on 12q21, we detected genome-wide linkage (LOD_eq 3.38) to the bivariate trait TC-LDL. Telomeric of this region, on 12q24, we found suggestive bivariate linkage to TC-HDL (LOD_eq 3.22) in the combined study sample. In addition, we detected suggestive univariate linkage (LOD 1.9–2.93) on chromosomes 4p-q, 6p, 7q, 9q, 11q, 12q 13q, 15q, 16p, 18q, 19p, 19q and Xq23 and suggestive bivariate linkage (LOD_eq 2.05–2.62) on chromosomes 6p, 7q, 12p, 12q, and 19p-q. In conclusion, chromosome 6p and 12q may host promising susceptibility loci influencing lipid levels; however, the low degree of overlap between the three study samples strongly encourages further studies of the lipid-related traits.

Supplementary key words environmental effects • genetic linkage analysis • variance component analysis • total cholesterol • low density lipoprotein • high density lipoprotein • triglyceride

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?