J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Originally published In Press as doi:10.1194/jlr.M800271-JLR200 on July 9, 2008

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Journal of Lipid Research, Vol. 49, 2414-2418, November 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Replacement of dietary saturated FAs by PUFAs in diet and reverse cholesterol transport

I. Kralova Lesna1, P. Suchanek, J. Kovar, P. Stavek and R. Poledne

Institute for Clinical and Experimental Medicine, Center for Cardiovascular Research, Prague, Czech Republic

Published, JLR Papers in Press, July 9, 2008.

This work was financially supported by Internal Grant Agency of the Ministry of Health of the Czech Republic, Project NR 8486-4.

1 To whom correspondence should be addressed. e-mail: ivka{at}ikem.cz

Dietary intervention is the first and usually successful approach in the treatment of high LDL cholesterol (LDL-C) concentration, but it is frequently accompanied by a decrease in HDL concentration. We studied 14 male volunteers on two different diets, high saturated fatty acid (SFA) and high PUFA, in a crossover design to test whether a decrease in HDL can affect reverse cholesterol transport from relabeled macrophages. A significant decrease of LDL-C (in mmol/l) after a PUFA diet compared with an SFA diet from 3.15 ± 0.65 to 2.80 ± 0.56 (P < 0.01) was accompanied by a significant decrease of HDL cholesterol (HDL-C) (in mmol/l) from 1.21 ± 0.30 to 1.10 ± 0.32 (P < 0.05). These changes did not affect cholesterol efflux (CHE) from macrophages (9.74 ± 1.46% vs. 9.53 ± 1.41%). There was no correlation between individual changes of HDL-C and changes of CHE. It is concluded that the decrease of HDL-C after successful dietary intervention of LDL-C is not accompanied by a decrease of CHE.

Supplementary key words fatty acids • cholesterol efflux • macrophages

Abbreviations: ABCG1, adenosine triphosphate binding cassette transporter G1; apo, apolipoprotein; CHD, coronary heart disease; FAFA, fatty acid-free bovine serum albumin; MUFA, monounsaturated fatty acid; NEFA, non-esterified fatty acid; RCT, reverse cholesterol transport; SFA, saturated fatty acid; SR-BI, scavenger receptor class B type 1


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