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Journal of Lipid Research, Vol. 49, 369-375, February 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population

Na-Ping Tang^1,*, Lian-Sheng Wang^1,, Li Yang^1,, Bo Zhou^1,*, Hai-Juan Gu^*, Qing-Min Sun^*, Ri-Hong Cong^*, Huai-Jun Zhu^* and Bin Wang^2,*

^* Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Published, JLR Papers in Press, November 6, 2007.

¹ N-P. Tang, L-S. Wang, L. Yang, and B. Zhou contributed equally to this work.

² To whom correspondence should be addressed. e-mail: binwang{at}njmu.edu.cn

The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population. The study population consisted of 265 CAD patients and 265 age- and sex-matched control subjects. The T allele frequency was significantly lower among CAD patients than among control subjects (18.3% vs. 29.8%; P < 0.001). In both the CAD and control groups, the T allele carriers had higher high density lipoprotein cholesterol (HDL-C) levels than homozygote C allele carriers. In a multiple logistic regression model adjusted for age, sex, body mass index, smoking, hypertension, diabetes, hyperlipidemia, and low density lipoprotein cholesterol, a significantly decreased risk of developing CAD was found in subjects carrying a variant CT or TT genotype (odds ratio = 0.496, 95% confidence interval = 0.341–0.723; P < 0.001), and the significance persisted after further adjustment for HDL-C. In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.

Supplementary key words genetic variant • polymorphism • high density lipoprotein cholesterol

Abbreviations: AMI, acute myocardial infarction; BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; EL, endothelial lipase; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; OR, odds ratio; TC, total cholesterol; TG, triglyceride

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