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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.P700019-JLR200 on December 18, 2007

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Journal of Lipid Research, Vol. 49, 670-678, March 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

Gissette Reyes, Koichi Yasunaga, Eileen Rothenstein, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran and Henry N. Ginsberg1

Departments of Medicine and Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032

Published, JLR Papers in Press, December 18, 2007.

1 To whom correspondence should be addressed. e-mail: hng1{at}columbia.edu

Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 ± 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 ± 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 ± 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.

Supplementary key words triglycerides • lipoproteins • hypertriglyceridemia


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