J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.M700112-JLR200 on February 8, 2008

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Journal of Lipid Research, Vol. 49, 945-953, May 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of genderboxs

Estibaliz Olano-Martin*, Elizheeba C. Abraham*, Rosalynn Gill-Garrison{dagger}, Ana M. Valdes{dagger},§, Keith Grimaldi{dagger}, Fiona Tang*, Kim G. Jackson*, Christine M. Williams* and Anne M. Minihane1,*

* Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences, and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom
{dagger} Sciona, Inc., Boulder, CO 80302
§ Twin Research Unit, King's College London, London WC2R 2LS, United Kingdom

boxs The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of one figure.

Published, JLR Papers in Press, February 8, 2008.

1 To whom correspondence should be addressed. e-mail: a.m.minihane{at}reading.ac.uk

Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (–1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V –1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender x genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males. Lower HDL-cholesterol was associated with the rare TC genotype (P = 0.047). Significant linkage disequilibrium was found between the apoA-V –1131 T>C and the apoC-III 3238 C>G variants, with univariate analysis indicating an impact of this apoC-III single nucleotide polymorphism (SNP) on TG AUC (P = 0.015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V –1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype.

Supplementary key words polymorphism • apolipoprotein A-V • apoA1/C3/A4/A5 gene locus • postprandial lipemia


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