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Journal of Lipid Research, Vol. 49, 1912-1917, September 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

Josefin Ahnström^1,*, Olof Axler^1,*, Matti Jauhiainen, Veikko Salomaa, Aki S. Havulinna, Christian Ehnholm, Ruth Frikke-Schmidt^**, Anne Tybjærg-Hansen^** and Björn Dahlbäck^2,*

^* Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmö, Sweden
National Public Health Institute, Department of Molecular Medicine, Biomedicum, Helsinki, Finland
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
^** Department of Clinical Biochemistry, Rigshospitalet, and The Copenhagen City Heart Study, Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark

Published, JLR Papers in Press, May 19, 2008.

This work was supported by grants from the Swedish Research Council (#71430), the Swedish Heart-Lung foundation, the Påhlsson's foundation, and research funds from the University Hospital in Malmö, Sigrid Juselius Foundation, Finnish Foundation for Cardiovascular Research, and the Division of Health, Academy of Finland.

¹ J. Ahnström and O. Axler contributed equally to this work.

² To whom correspondence should be addressed. e-mail: bjorn.dahlback{at}med.lu.se

Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-β-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74–1.27) and 0.92 (0.84–1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study.

Supplementary key words cholesterol • lipocalin • signal peptide • FINRISK • Copenhagen City Heart Study

Abbreviations: apoM, apolipoprotein M; CCHS, Copenhagen City Heart Study; CHD, coronary heart disease; LRH-1, liver receptor homolog-1; SNP, single-nucleotide polymorphism

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