HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zbinden, G. Search for Related Content PubMed PubMed Citation Articles by Zbinden, G. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 5, 378-384, July 1964
Copyright © 1964 by Lipid Research, Inc.

Transient thrombopenia after intravenous injection of certain fatty acids

Gerhard Zbinden

Research Division, Hoffmann-La Roche Inc., Nutley, New Jersey

Intravenous injections of various fatty acids in rabbits caused marked thrombopenia lasting 1-2 hr. The most active saturated fatty acids were myristic acid (14:0) and lauric acid (12:0). Activity decreased with increasing and decreasing chain length, but behenic acid (22:0) had, on a molar basis, activity similar to that of lauric acid. Of the unsaturated fatty acids, oleic acid (18:1) was active only at high doses, whereas linoleic (18:2) and linolenic acid (18:3) had an effect comparable to palmitic acid (16:0). Intraperitoneal administration of the fatty acids caused no thrombopenia. The thrombopenic effect of the fatty acids was greatly reduced if the solutions were mixed with serum before injection.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?