Journal of Lipid Research, Vol. 5, 459-467, July 1964
Copyright © 1964 by Lipid Research, Inc.

The uptake of doubly labeled chylomicrons by guinea pig mammary gland and liver

O. W. McBride and Edward D. Korn

Laboratory of Biochemistry, Section on Cellular Physiology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The uptake of cholesterol-H³-palmitate-C¹⁴-chylomicrons by mammary tissue and liver has been examined. The cholesterol and glyceride components of chylomicrons were taken up at the same rate by both liver and mammary tissue, as demonstrated by the unchanged ratio of C¹⁴/H³ in the tissue lipids compared to the chylomicrons. However, following injection of glycerol-C¹⁴-palmitate-H³-chylomicrons, the H³/C¹⁴ ratio of the lipids of mammary tissue was much greater than the H³/C¹⁴ ratios of the injected chylomicrons, of the serum lipids, or of the liver lipids, indicating that appreciable hydrolysis of chylomicron glycerides occurred during their uptake by mammary glands. This is consistent with the hypothesis that lipoprotein lipase is involved in the uptake of chylomicron glyceride by mammary gland.

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