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Journal of Lipid Research, Vol. 5, 569-577, October 1964
Copyright © 1964 by Lipid Research, Inc.

Effect of carbon tetrachloride ingestion on liver and plasma triglyceride turnover rates

Michael C. Schotz , Nome Baker , and Margarito N. Chavez

Radioisotope Research, Veterans Administration Center and Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, California

Specific and total radioactivity of liver and serum triglycerides were determined at various times after palmitate-1-C¹⁴ injection in carbon tetrachloride-treated and control rats. A multicompartmental model of plasma and liver triglyceride metabolism was used to calculate, with the aid of a digital computer, transfer rates from one compartment to another.

Analysis of the data indicates that carbon tetrachloride ingestion results in a lowering of the rate of hepatic triglyceride secretion to one-tenth of the control value. In addition, the rates of plasma triglyceride turnover and of hepatic uptake of plasma triglyceride were found to be only one-fifth of the control rates. The results are compatible with a hypothesis of disruption of hepatic mechanisms involved in the synthesis of triglyceride-protein complexes, in their secretion, or both.

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