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Journal of Lipid Research, Vol. 5, 616-623, October 1964
Copyright © 1964 by Lipid Research, Inc.

Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines

D. L. Turner , M. J. Silver , E. Baczynski , N. Giordano , and I. Rodalewicz

The Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

The synthesis of racemic 1,2-dioleoyl and 1-oleoyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-DL-serine.

The synthetic phosphatidyl serines were tested in blood cloting systems in vitro. They have activity qualitatively similar to that of naturally occurring phosphatidyl serines: anticoagulant activity when well solubilized and weak to moderate thromboplastic activity in simple suspension.

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