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J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.M800135-JLR200 on August 27, 2008

Papers In Press, published online ahead of print January 1, 2009
J. Lipid Res., doi:10.1194/jlr.M800135-JLR200
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Journal of Lipid Research, Vol. 50, 41-46, January 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in ratsboxs

Makoto Asahina, Waka Haruyama, Yasuhiro Ichida, Mai Sakamoto, Masao Sato and Katsumi Imaizumi1

Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan

boxs The online version of this article (available at http://www.jlr.org) contains supplementary Materials and Methods.

Published, JLR Papers in Press, August 27, 2008.

This study was supported by the National Bio Resource Project for the Rat in Japan. This study was supported in part by Grants-in-aid for Scientific Research (B2; 16380090 and B; 18380083).

1 To whom correspondence should be addressed. e-mail: imaizumi{at}agr.kyushu-u.ac.jp

We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.

Supplementary key words ExHC rat • diet-induced hypercholesterolemia • congenic strains • interval-specific congenic lines


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