HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: R900012-JLR200v1 50/12/2340    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Dawson, P. A. Articles by Rao, A. PubMed PubMed Citation Articles by Dawson, P. A. Articles by Rao, A. Related Collections Related Webpages Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 50, 2340-2357, December 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Thematic Review

Bile acid transporters

Paul A. Dawson¹, Tian Lan and Anuradha Rao

Department of Internal Medicine and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157

¹ To whom correspondence should be addressed. e-mail: pdawson{at}wfubmc.edu

In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and unraveling their complex regulation. In the liver, bile acids are efficiently transported across the sinusoidal membrane by the Na⁺ taurocholate cotransporting polypeptide with assistance by members of the organic anion transporting polypeptide family. The bile acids are then secreted in an ATP-dependent fashion across the canalicular membrane by the bile salt export pump. Following their movement with bile into the lumen of the small intestine, bile acids are almost quantitatively reclaimed in the ileum by the apical sodium-dependent bile acid transporter. The bile acids are shuttled across the enterocyte to the basolateral membrane and effluxed into the portal circulation by the recently indentified heteromeric organic solute transporter, OST-OSTβ. In addition to the hepatocyte and enterocyte, subgroups of these bile acid transporters are expressed by the biliary, renal, and colonic epithelium where they contribute to maintaining bile acid homeostasis and play important cytoprotective roles. This article will review our current understanding of the physiological role and regulation of these important carriers.

Supplementary key words bile acids • cholesterol • nuclear receptors • cholestasis • enterohepatic circulation

Abbreviations: ASBT, apical sodium-dependent bile acid transporter; BRIC, benign recurrent intrahepatic cholestasis; BSEP, bile salt export pump; FXR, farnesoid X receptor; HNF, hepatocyte nuclear factor; IL, interleukin; JNK, Jun N-terminal kinase; LPS, lipopolysaccharide; LRH, liver receptor homolog; MRP, multidrug resistance protein; NTCP, Na⁺ taurocholate cotransporting polypeptide; OATP, organic anion transporting polypeptide; OST, organic solute transporter; PFIC, progressive familial intrahepatic cholestasis; RAR/RXR, retinoic acid receptor/retinoid X receptor; SHP, small heterodimer partner; TNF, tumor necrosis factor alpha

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Webpages: