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Journal of Lipid Research, Vol. 50, 2532-2539, December 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

Persistence of an atherogenic lipid profile after treatment of acute infection with brucella

F. Apostolou^*, I. F. Gazi^*, A. Kostoula, C. C. Tellis, A. D. Tselepis, M. Elisaf^1,* and E. N. Liberopoulos^*

^* Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece
Department of Microbiology, University Hospital of Ioannina, Ioannina, Greece
Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

¹ To whom correspondence should be addressed. e-mail: egepi{at}cc.uoi.gr

Serum lipid changes during infection may be associated with atherogenesis. No data are available on the effect of Brucellosis on lipids. Lipid parameters were determined in 28 patients with Brucellosis on admission and 4 months following treatment and were compared with 24 matched controls. Fasting levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) A, B, E CII, and CIII, and oxidized LDL (oxLDL) were measured. Activities of serum cholesterol ester transfer protein (CETP), paraoxonase 1 (PON1), and lipoprotein-associated phospholipase A₂ (Lp-PLA₂) and levels of cytokines [interleukins (IL)-1β, IL-6, and tumor necrosis factor (TNFa)] were also determined. On admission, patients compared with controls had 1) lower levels of TC, HDL-C, LDL-cholesterol (LDL-C), ApoB, ApoAI, and ApoCIII and higher LDL-C/HDL-C and ApoB/ApoAI ratios; 2) higher levels of IL-1b, IL-6, and TNFa; 3) similar ApoCII and oxLDL levels and Lp-PLA₂ activity, lower PON1, and higher CETP activity; and 4) higher small dense LDL-C concentration. Four months later, increases in TC, HDL-C, LDL-C, ApoB, ApoAI, and ApoCIII levels, ApoB/ApoAI ratio, and PON1 activity were noticed compared with baseline, whereas CETP activity decreased. LDL-C/HDL-C ratio, ApoCII, and oxLDL levels, Lp-PLA₂ activity, and small dense LDL-C concentration were not altered. Brucella infection is associated with an atherogenic lipid profile that is not fully restored 4 months following treatment.

Supplementary key words small dense low density lipoprotein • cytokines • lipoprotein-associated phospholipase A₂ • paraoxonase 1 • cholesterol ester transfer protein • oxidized low density lipoprotein

Abbreviations: Apo, apolipoprotein; CETP, cholesterol ester transfer protein; CRP, C-reactive protein; CV, coefficients of variation; HDL-C, HDL-cholesterol; IgA, immunoglobulin; IL, interleukin; LDL-C, LDL-cholesterol; Lp(a), lipoprotein (a); Lp-PLA₂, lipoprotein-associated phospholipase A₂; LPS, lipopolysaccharide; oxLDL, oxidized LDL; PAF, platelet-activating factor; PON1, paraoxonase 1; sdLDL, small dense LDL; TC, total cholesterol; TG, triglyceride; TNF, tumor necrosis factor

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