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Journal of Lipid Research, Vol. 50, 880-884, May 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels

S. F. C. Vaessen^*, G. M. Dallinga-Thie^*, C. J. D. Ross, L. J. Splint^*, L. W. Castellani, P. C. N. Rensen^**, M. R. Hayden, F. G. Schaap and J. A. Kuivenhoven^1,*

^* Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
University of British Columbia, Center for Molecular Medicine and Therapeutics, Vancouver, Canada
Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA
^** Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Published, JLR Papers in Press, January 13, 2009.

¹ To whom correspondence should be addressed. e-mail: j.a.kuivenhoven{at}amc.uva.nl

Apolipoprotein AV (apoAV) overexpression causes a decrease in plasma triglyceride (TG) levels, while deficiency of apoAV causes hypertriglyceridemia in both men and mice. However, contrary to what would be expected, plasma apoAV and TG levels in humans are positively correlated. To address this apparent paradox, we determined plasma apoAV levels in various mouse models with median TG levels ranging from 30 mg/dl in wild-type mice to 2089 mg/dl in glycosylphosphatidylinositol-anchored HDL binding protein 1-deficient mice. The data show that apoAV and TG levels are positively correlated in mice (r = +0.798, P < 0.001). In addition, we show that LPL gene transfer caused a simultaneous decrease in TG and apoAV in LPL-deficient mice. The combined data suggest that apoAV levels follow TG levels due to an intimate link between the apoAV molecule and TG-rich lipoproteins, comprising both secretion and removal of these lipoproteins. Taken together, the data suggest that higher plasma apoAV levels reflect an increased demand for plasma TG hydrolysis under normal physiological conditions.

Supplementary key words lipoproteins • lipolysis • VLDL • chylomicrons

Abbreviations: apoAV, apolipoprotein AV; GPIHBP, glycosylphosphatidylinositol-anchored HDL binding protein-deficient; TG, triglyceride

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