HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: P900012-JLR200v1 50/7/1472    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Anuurad, E. Articles by Berglund, L. Search for Related Content PubMed PubMed Citation Articles by Anuurad, E. Articles by Berglund, L. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 50, 1472-1478, July 2009
Copyright © 2009 by American Society for Biochemistry and Molecular Biology

Patient-Oriented and Epidemiological Research

ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans

Erdembileg Anuurad^*, Masayuki Yamasaki^*,, Neil Shachter, Thomas A. Pearson^** and Lars Berglund^1,*,

^* Department of Medicine, University of California, Davis, CA
Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Shimane, Japan
Department of Medicine, Columbia University, New York, NY
^** Department of Family and Community Medicine, University of Rochester, Rochester, NY
Veterans Affairs (VA) Northern California Health Care System, Mather, CA

This study was supported by Grants 49735 (T.A.P.) and 62705 (L.B.) from the National Heart, Lung and Blood Institute of the National Institutes of Health. This work was supported in part by Grant RR-024146 from the Clinical and Translational Science Center, University of California at Davis.

Published, JLR Papers in Press, February 27, 2009.

¹ To whom correspondence should be addressed. e-mail: lars.berglund{at}ucdmc.ucdavis.edu

Apolipoproteins (apo) E and C-I are components of triglyceride (TG)-rich lipoproteins and impact their metabolism. Functional polymorphisms have been established in apoE but not in apoC-I. We studied the relationship between apoE and apoC-I gene polymorphisms and plasma lipoproteins and coronary artery disease (CAD) in 211 African Americans and 306 Caucasians. In African Americans but not in Caucasians, apoC-I H2-carriers had significantly lower total and LDL cholesterol and apoB levels, and higher glucose, insulin, and HOMA-IR levels compared with H1 homozygotes. Differences across CAD phenotypes were seen for the apoC-I polymorphism. African-American H2-carriers without CAD had significantly lower total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and apoB (P < 0.001) levels compared with H1 homozygotes, whereas no differences were found across apoC-I genotypes for African Americans with CAD. Among African-American apoC-I H1 homozygotes, subjects with CAD had a profile similar to the metabolic syndrome (i.e., higher triglyceride, glucose, and insulin) compared with subjects without CAD. For African-American H2-carriers, subjects with CAD had a pro-atherogenic lipid pattern (i.e., higher LDL cholesterol and apoB levels), compared with subjects without CAD. ApoC-I genotypes showed an ethnically distinct phenotype relationship with regard to CAD and CAD risk factors.

Supplementary key words apolipoprotein C-I • apolipoprotein E • coronary artery disease • ethnicity • polymorphism

Abbreviations: Apo, apolipoprotein; CAD, coronary artery disease; CETP, cholesteryl ester transfer protein; CVD, cardiovascular disease; HOMA-IR, homeostasis model assessment-insulin resistance; LCAT, lecithin cholesterol acyltransferase; LRP, LDL receptor-related protein; TG, triglyceride

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?